Title:
IMMUNE ADJUVANT FOR CANCER
Document Type and Number:
WIPO Patent Application WO/2018/021400
Kind Code:
A1
Abstract:
The present invention relates to a medicine for treating cancer or an infectious disease, said medicine comprising a combination of an immune check point inhibitor with an adjuvant composition. More specifically, the present invention relates to a medicine for cancer or an infectious disease, said medicine being characterized by using an anti-PD-1 antibody or an anti-PD-L1 antibody together with a nucleic acid adjuvant comprising a double-stranded RNA and a single-stranded ODN.
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Inventors:
SEYA TSUKASA (JP)
MATSUMOTO MISAKO (JP)
MATSUMOTO MISAKO (JP)
Application Number:
PCT/JP2017/027027
Publication Date:
February 01, 2018
Filing Date:
July 26, 2017
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K39/395; A61K39/02; A61K39/12; A61K39/39; A61P31/00; A61P31/04; A61P31/06; A61P31/12; A61P31/16; A61P31/18; A61P31/22; A61P33/02; A61P33/06; A61P35/00; A61P35/02
Domestic Patent References:
| WO2016019472A1 | 2016-02-11 | |||
| WO2012014945A1 | 2012-02-02 | |||
| WO2016088784A1 | 2016-06-09 | |||
| WO2008065752A1 | 2008-06-05 | |||
| WO2012014945A1 | 2012-02-02 | |||
| WO2016088784A1 | 2016-06-09 |
Foreign References:
| JP2014527983A | 2014-10-23 | |||
| JP2016147657A | 2016-08-18 | |||
| JP2017079445A | 2017-04-27 |
Other References:
TSUKASA SEYA ET AL.: "Priming adjuvant for evoking antitumor immunity", RINSHO TO KENKYU - JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 256, no. 7, 13 February 2016 (2016-02-13), pages 811 - 816, XP009513334, ISSN: 0021-4965
ITOH ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 181, no. 8, 2008, pages 5522 - 5529
MATSUMOTO ET AL., NATURE COMMUNICATIONS, vol. 6, 2015, pages 6280
MATSUMOTO M.; T. SEYA: "TLR3: Interferon induction by double-stranded RNA including poly(I:C", ADV. DRUG DEL. REV., vol. 60, 2008, pages 805 - 812, XP022585997, DOI: doi:10.1016/j.addr.2007.11.005
SHINGAI ET AL., J IMMUNOL., vol. 179, 2007, pages 6123 - 6133
ITOH ET AL., THE JOURNAL OF IMMUNOLOGY, 2008
MATSUMOTO ET AL., NAT. COMMUN., 2015
SHINGAI ET AL., J IMMUNOL., vol. 179, no. 9, 1 November 2007 (2007-11-01), pages 6123 - 6133
J NATL CANCER INST., vol. 57, no. 3, September 1976 (1976-09-01), pages 599 - 602
SHIME ET AL., PROC. NATL. ACAD. SCI. U. S. A., vol. 109, no. 6, 2012, pages 2066 - 2071
KATAOKA ET AL., NATURE, vol. 534, 2016, pages 402
See also references of EP 3492098A4
ITOH ET AL., THE JOURNAL OF IMMUNOLOGY, vol. 181, no. 8, 2008, pages 5522 - 5529
MATSUMOTO ET AL., NATURE COMMUNICATIONS, vol. 6, 2015, pages 6280
MATSUMOTO M.; T. SEYA: "TLR3: Interferon induction by double-stranded RNA including poly(I:C", ADV. DRUG DEL. REV., vol. 60, 2008, pages 805 - 812, XP022585997, DOI: doi:10.1016/j.addr.2007.11.005
SHINGAI ET AL., J IMMUNOL., vol. 179, 2007, pages 6123 - 6133
ITOH ET AL., THE JOURNAL OF IMMUNOLOGY, 2008
MATSUMOTO ET AL., NAT. COMMUN., 2015
SHINGAI ET AL., J IMMUNOL., vol. 179, no. 9, 1 November 2007 (2007-11-01), pages 6123 - 6133
J NATL CANCER INST., vol. 57, no. 3, September 1976 (1976-09-01), pages 599 - 602
SHIME ET AL., PROC. NATL. ACAD. SCI. U. S. A., vol. 109, no. 6, 2012, pages 2066 - 2071
KATAOKA ET AL., NATURE, vol. 534, 2016, pages 402
See also references of EP 3492098A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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