Title:
IMMUNE CELL TREATMENT OF NERVE DAMAGE
Document Type and Number:
WIPO Patent Application WO/2020/009437
Kind Code:
A1
Abstract:
The present invention relates to a composition for treating a nerve damage, comprising natural killer cells, immune cells, or a substance for increasing the activity of the cells, and the natural killer cells, immune cells, or substance for increasing the activity of the cells, according to one aspect, can be usefully used in a fundamental treatment of a neurological disorder due to a nerve damage or an abnormal nerve, by allowing the natural killer cells to invade a damaged nerve part and directly remove damaged nerve cells.
Inventors:
OH SEOG BAE (KR)
DAVIES ALEXANDER JAMES (KR)
KIM HYOUNG WOO (KR)
DAVIES ALEXANDER JAMES (KR)
KIM HYOUNG WOO (KR)
Application Number:
PCT/KR2019/008066
Publication Date:
January 09, 2020
Filing Date:
July 02, 2019
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K35/17; A61K38/20; A61K38/21; A61P25/00; C12N5/0783
Foreign References:
| US20070244066A1 | 2007-10-18 |
Other References:
"The Response and Function of Natural Killer Cells After Peripheral Nerve Injury and Their Contribution to Neuropathic Pain", SCIENCE AND ENGINEERING PERSONAL FUNDAMENTAL RESEARCH SUPPORT BUSINESS FINAL REPORT, pages 1 - 17
BOLLINO, D. ET AL.: "Chimeric antigen receptor-engineered natural killer and natural killer T cells for cancer immunotherapy", TRANSLATIONAL RESEARCH, vol. 187, 2017, pages 32 - 43, XP085184174, DOI: 10.1016/j.trsl.2017.06.003
CUI, J.--G. ET AL.: "Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy", PAIN, vol. 88, 2000, pages 239 - 248, XP027336213
POLI, A. ET AL.: "NK cells in central nervous system disorders", THE JOURNAL OF IMMUNOLOGY, vol. 190, no. 11, 17 May 2013 (2013-05-17), pages 5355 - 5362, XP055673211
DAVIES, A. J. ET AL.: "Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury", CELL, vol. 176, no. 4, 7 February 2019 (2019-02-07), pages 716 - 728, XP055673230
BOLLINO, D. ET AL.: "Chimeric antigen receptor-engineered natural killer and natural killer T cells for cancer immunotherapy", TRANSLATIONAL RESEARCH, vol. 187, 2017, pages 32 - 43, XP085184174, DOI: 10.1016/j.trsl.2017.06.003
CUI, J.--G. ET AL.: "Possible role of inflammatory mediators in tactile hypersensitivity in rat models of mononeuropathy", PAIN, vol. 88, 2000, pages 239 - 248, XP027336213
POLI, A. ET AL.: "NK cells in central nervous system disorders", THE JOURNAL OF IMMUNOLOGY, vol. 190, no. 11, 17 May 2013 (2013-05-17), pages 5355 - 5362, XP055673211
DAVIES, A. J. ET AL.: "Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury", CELL, vol. 176, no. 4, 7 February 2019 (2019-02-07), pages 716 - 728, XP055673230
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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