Title:
IMMUNE CELLS HAVING CO-EXPRESSED TGFBR SHRNAS
Document Type and Number:
WIPO Patent Application WO/2024/059618
Kind Code:
A3
Abstract:
Provided herein are recombinant nucleic acids that reduce expression of TGFBR1 and/or TGFBR2 and cells comprising such recombinant nucleic acids. Also provided are methods of making and using such cells.
Inventors:
GAGNON JOHN (US)
LITTERMAN ADAM (US)
CASBON AMY-JO (US)
SINGH BRENAL (US)
HALL JASON (US)
BEZMAN NATALIE (US)
COOPER AARON (US)
GRAY-RUPP LEVI (US)
LITTERMAN ADAM (US)
CASBON AMY-JO (US)
SINGH BRENAL (US)
HALL JASON (US)
BEZMAN NATALIE (US)
COOPER AARON (US)
GRAY-RUPP LEVI (US)
Application Number:
PCT/US2023/074047
Publication Date:
April 25, 2024
Filing Date:
September 13, 2023
Export Citation:
Assignee:
ARSENAL BIOSCIENCES INC (US)
International Classes:
C12N15/113; A61K31/713
Domestic Patent References:
| WO2008109546A2 | 2008-09-12 | |||
| WO2021009701A1 | 2021-01-21 | |||
| WO2019178422A1 | 2019-09-19 | |||
| WO2021097521A1 | 2021-05-27 | |||
| WO2020206248A1 | 2020-10-08 | |||
| WO2022162247A1 | 2022-08-04 |
Foreign References:
| US20220235380A1 | 2022-07-28 |
Other References:
KUESPERT SABRINA ET AL: "Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGF[beta] Signaling", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 6, 12 March 2020 (2020-03-12), Basel, CH, pages 1952, XP093110457, ISSN: 1422-0067, DOI: 10.3390/ijms21061952
GHORBAN ALI TARFIEI ET AL: "GDF15 induced apoptosis and cytotoxicity in A549 cells depends on TGFBR2 expression", CELL BIOCHEMISTRY AND FUNCTION, BUTTERWORTH, GUILDFORD, GB, vol. 37, no. 5, 7 June 2019 (2019-06-07), pages 320 - 330, XP071522881, ISSN: 0263-6484, DOI: 10.1002/CBF.3391
WANG YANG ET AL: "MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2", CELL DEATH & DISEASE, vol. 8, no. 5, 18 May 2017 (2017-05-18), GB, pages e2792, XP093110471, ISSN: 2041-4889, Retrieved from the Internet DOI: 10.1038/cddis.2017.10
ZHANG LAN ET AL: "Network-based Transcriptome-wide Expression Study for Postmenopausal Osteoporosis", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 105, no. 8, 1 August 2020 (2020-08-01), US, pages 2678 - 2691, XP093110466, ISSN: 0021-972X, Retrieved from the Internet DOI: 10.1210/clinem/dgaa319
GARDNER THOMAS ET AL: "Abstract 1768: Multiplexed shRNA cassettes targeting orthogonal pathways (FAS/PTPN2/TGFBR) enhance the potency of integrated circuit T cells (ICTs) in multiple solid tumor models", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 83, no. 7_Supplement, 4 April 2023 (2023-04-04), pages 1768, XP009550617, ISSN: 0099-7374, DOI: 10.1158/1538-7445.AM2023-1768
GHORBAN ALI TARFIEI ET AL: "GDF15 induced apoptosis and cytotoxicity in A549 cells depends on TGFBR2 expression", CELL BIOCHEMISTRY AND FUNCTION, BUTTERWORTH, GUILDFORD, GB, vol. 37, no. 5, 7 June 2019 (2019-06-07), pages 320 - 330, XP071522881, ISSN: 0263-6484, DOI: 10.1002/CBF.3391
WANG YANG ET AL: "MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2", CELL DEATH & DISEASE, vol. 8, no. 5, 18 May 2017 (2017-05-18), GB, pages e2792, XP093110471, ISSN: 2041-4889, Retrieved from the Internet
ZHANG LAN ET AL: "Network-based Transcriptome-wide Expression Study for Postmenopausal Osteoporosis", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 105, no. 8, 1 August 2020 (2020-08-01), US, pages 2678 - 2691, XP093110466, ISSN: 0021-972X, Retrieved from the Internet
GARDNER THOMAS ET AL: "Abstract 1768: Multiplexed shRNA cassettes targeting orthogonal pathways (FAS/PTPN2/TGFBR) enhance the potency of integrated circuit T cells (ICTs) in multiple solid tumor models", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 83, no. 7_Supplement, 4 April 2023 (2023-04-04), pages 1768, XP009550617, ISSN: 0099-7374, DOI: 10.1158/1538-7445.AM2023-1768
Attorney, Agent or Firm:
LANGE, Kevin et al. (US)
Download PDF: