Title:
IMMUNE CELLS HAVING NANOSTRUCTURE ATTACHED THERETO
Document Type and Number:
WIPO Patent Application WO/2021/137611
Kind Code:
A1
Abstract:
The present invention relates to an immune cell having a nanostructure attached thereto and a use thereof. According to the present invention, a nanostructure including a linker and/or a carrier that is degraded by hydrogen peroxide is conjugated via a ligand to an immune cell having CD45 present on the cell membrane thereof, whereby the activity of the immune cell can be improved. In addition, a hydrogen peroxide environment-specific immune response can be made through the linker and/or the carrier. Having such properties, the cell can therefore be effectively utilized for preventing and treating diseases such as cancer or inflammation.
Inventors:
HWANG DO WON (KR)
KI YOUNG WOOK (KR)
LEE DONG WON (KR)
YOO DONG HYUK (KR)
KIM SOO MIN (KR)
KI YOUNG WOOK (KR)
LEE DONG WON (KR)
YOO DONG HYUK (KR)
KIM SOO MIN (KR)
Application Number:
PCT/KR2020/019375
Publication Date:
July 08, 2021
Filing Date:
December 30, 2020
Export Citation:
Assignee:
THERABEST CO LTD (KR)
International Classes:
A61K47/69; A61K9/51; A61K38/19; A61K47/10; A61K47/20; A61K47/24; A61P35/00
Foreign References:
| US20170080104A1 | 2017-03-23 | |||
| US20140017170A1 | 2014-01-16 | |||
| KR101963327B1 | 2019-03-28 | |||
| KR20190053203A | 2019-05-17 | |||
| KR20160085794A | 2016-07-18 | |||
| KR20190038540A | 2019-04-08 |
Other References:
ECKMANN D. M., COMPOSTO R. J., TSOURKAS A., MUZYKANTOV V. R.: "Nanogel carrier design for targeted drug delivery", JOURNAL OF MATERIALS CHEMISTRY. B, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 2, no. 46, 1 January 2014 (2014-01-01), GB, pages 8085 - 8097, XP055826295, ISSN: 2050-750X, DOI: 10.1039/C4TB01141D
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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