Title:
IMMUNE CHECKPOINT INHIBITOR CONJUGATED WITH ULTRASONIC SENSITIZER, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/124664
Kind Code:
A1
Abstract:
The present invention relates to an immune checkpoint inhibitor conjugated with an ultrasound sensitizer, a use thereof, and the like. The immune checkpoint inhibitor conjugate conjugated with an ultrasound sensitizer according to the present invention has selectivity for tumors with respect to targeted therapy and specifically responds to ultrasonic waves, and thus can be used to produce drugs for diagnosing and treating cancer. Particularly, the conjugate of the present invention exhibits excellent solubility and stability in an aqueous solution, and provides excellent anticancer effects as compared with simple immune checkpoint inhibitors, and therefore, is expected to be useful as a novel drug for treating cancer.
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Inventors:
KIM DAEHYUN (KR)
KIM YOON-SEOK (KR)
KIM HYUN RYOUNG (KR)
JUNG EUN AH (KR)
KIM YOON-SEOK (KR)
KIM HYUN RYOUNG (KR)
JUNG EUN AH (KR)
Application Number:
PCT/KR2021/017744
Publication Date:
June 16, 2022
Filing Date:
November 29, 2021
Export Citation:
Assignee:
IMGT CO LTD (KR)
International Classes:
A61K47/54; A61K39/00; A61K49/22; A61P35/00
Domestic Patent References:
| WO2020115491A2 | 2020-06-11 |
Foreign References:
| KR20190103999A | 2019-09-05 | |||
| US6498945B1 | 2002-12-24 | |||
| KR20190001022A | 2019-01-04 | |||
| KR20200169867A |
Other References:
LI JINGCHAO, LUO YU, PU KANYI: "Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, vol. 60, no. 23, 1 June 2021 (2021-06-01), pages 12682 - 12705, XP055941907, ISSN: 1433-7851, DOI: 10.1002/anie.202008386
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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