Title:
IMMUNE EFFECTOR CELL EXPRESSING IL-15
Document Type and Number:
WIPO Patent Application WO/2021/057906
Kind Code:
A1
Abstract:
Provided is an immune effector cell expressing IL-15; the cells express IL-15 and recognize receptors for specific target antigens, or the cells express IL-15R binding molecules and receptors that recognize specific target antigens. Also provided are a nucleic acid molecule, an IL-15R binding molecule or IL-15 or IL-15 and chemokine expressed by said nucleic acid molecule, a chemokine receptor, a cytokine other than IL-7, an siRNA which reduces PD-1 expression, a protein which blocks the binding of PD-L1 to PD-1, or a safety switch.
Inventors:
LI ZONGHAI (CN)
JIANG HUA (CN)
JIANG HUA (CN)
Application Number:
PCT/CN2020/117759
Publication Date:
April 01, 2021
Filing Date:
September 25, 2020
Export Citation:
Assignee:
CARSGEN THERAPEUTICS CO LTD (CN)
SHANGHAI CANCER INST (CN)
SHANGHAI CANCER INST (CN)
International Classes:
A61K35/17; A61P35/00; C07K16/28; C12N5/10
Domestic Patent References:
| WO2017177337A1 | 2017-10-19 | |||
| WO2016138034A1 | 2016-09-01 | |||
| WO2015142675A2 | 2015-09-24 |
Foreign References:
| CN107635569A | 2018-01-26 | |||
| CN109311984A | 2019-02-05 | |||
| CN109562126A | 2019-04-02 | |||
| CN108884164A | 2018-11-23 | |||
| CN110272873A | 2019-09-24 | |||
| CN108949825A | 2018-12-07 |
Other References:
ALIZADEH, D. ET AL.: "IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype", CANCER IMMUNOLOGY RESEARCH, vol. 7, no. 5, 19 March 2019 (2019-03-19), pages 759 - 772, XP055776481, DOI: 20201124173409A
Attorney, Agent or Firm:
BEIJING CAIHE LAW FIRM (CN)
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