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Patent Searching and Data


Title:
IMMUNIGENIC ALPHA-BRANCHED TREHALOSE-DIESTERS
Document Type and Number:
WIPO Patent Application WO/2019/197595
Kind Code:
A3
Abstract:
The invention relates to compounds of formula (I) and their use in eliciting a pro-Thl7 immune response. Further provided are methods of production of said compounds. (Formula I) wherein m is an integer between 4 and 13; n is an integer between 4 and 13; x is an integer between 4 and 13; y is an integer between 4 and 13.

Inventors:
EVANS, Jay T (553 Old Corvallis RoadHamilton, Montana, 59840-3607, US)
SMITH, Alyson (553 Old Corvallis RoadHamilton, Montana, 59840-3607, US)
Application Number:
EP2019/059385
Publication Date:
November 21, 2019
Filing Date:
April 12, 2019
Export Citation:
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Assignee:
GLAXOSMITHKLINE BIOLOGICALS SA (Rue de l'Institut 89, Rixensart, B-1330, BE)
International Classes:
C07H13/04; A61K31/7024; A61P37/00
Foreign References:
US20110218171A12011-09-08
US8163713B22012-04-24
Other References:
SUNCHU PRABHAKAR ET AL: "A fully enzymatic esterification/transesterification sequence for the preparation of symmetrical and unsymmetrical trehalose diacyl conjugates", GREEN CHEMISTRY, vol. 19, no. 4, 1 January 2017 (2017-01-01), GB, pages 987 - 995, XP055609925, ISSN: 1463-9262, DOI: 10.1039/C6GC02680J
NUMATA FUMIO ET AL: "Lethal and adjuvant activities of cord factor (trehalose 6,6'-dimycolate) and synthetic analogs in mice", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 33, no. 10, 1 January 1985 (1985-01-01), pages 4544 - 4555, XP008111645, ISSN: 0009-2363
HIROFUMI YAMAMOTO ET AL: "Development of Vizantin, a Safe Immunostimulant, Based on the Structure-Activity Relationship of Trehalose-6,6'-dicorynomycolate", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 1, 4 December 2012 (2012-12-04), US, pages 381 - 385, XP055609937, ISSN: 0022-2623, DOI: 10.1021/jm3016443
Attorney, Agent or Firm:
FURSTOSS, Olivia (GlaxoSmithKline, Global Patents CN925.1980 Great West Road, Brentford Middlesex TW8 9GS, TW8 9GS, GB)
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