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Title:
IMMUNO-CELL THERAPY FOR ALLERGIC DISEASE USING REGULATORY DENDRITIC CELL
Document Type and Number:
WIPO Patent Application WO/2007/100154
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical composition for treatment of an allergic disease, which contains a regulatory dendritic cell. The composition comprises an antigen-specific IgE production inhibitor comprising a regulatory dendritic cell, wherein the regulatory dendritic cell is prepared by culturing an animal dendritic cell or a progenitor cell thereof in vitro in the presence of either GM-CSF or GM-CSF, IL-4, IL-10 and TGF-β1, culturing the cell in the presence of an antigen associated with the allergic disease, and then culturing the cell in the presence of either LPS or TNF-α or both of them.

Inventors:
SATO, Katsuaki (7-22 Suehiro-cho 1-chome, Tsurumi-ku, Yokohama-sh, Kanagawa 45, 2300045, JP)
佐藤克明 (〒45 神奈川県横浜市鶴見区末広町1丁目7番22号独立行政法人理化学研究所 横浜研究所内 Kanagawa, 2300045, JP)
ISHII, Yasuyuki (7-22 Suehiro-cho 1-chome, Tsurumi-ku, Yokohama-sh, Kanagawa 45, 2300045, JP)
Application Number:
JP2007/054613
Publication Date:
September 07, 2007
Filing Date:
March 02, 2007
Export Citation:
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Assignee:
RIKEN (2-1 Hirosawa, Wako-shi Saitama, 98, 3510198, JP)
独立行政法人理化学研究所 (〒98 埼玉県和光市広沢2番1号 Saitama, 3510198, JP)
KIRIN BEER KABUSHIKI KAISHA (10-1, Shinkawa 2-chome Chuo-k, Tokyo 88, 1048288, JP)
麒麟麦酒株式会社 (〒88 東京都中央区新川二丁目10番1号 Tokyo, 1048288, JP)
SATO, Katsuaki (7-22 Suehiro-cho 1-chome, Tsurumi-ku, Yokohama-sh, Kanagawa 45, 2300045, JP)
International Classes:
A61K35/12; A61K39/00; A61P11/06; A61P17/00; A61P37/08; C12N5/0784
Domestic Patent References:
WO2005120574A12005-12-22
Foreign References:
JP2004298181A2004-10-28
Other References:
BELLINGHAUSEN I. ET AL.: "INHIBITION OF HUMAN ALLERGIC T-HELPER TYPE 2 IMMUNE RESPONSES BY INDUCED REGULATORY T CELLS REQUIRES THE COMBINATION OF INTERLEUKIN-10-TREATED DENDRITIC CELLS AND TRANSFORMING GROWTH FACTOR- beta FOR THEIR FUNCTION", CLINICAL AND EXPERIMENTAL ALLERGY, vol. 36, no. 12, December 2006 (2006-12-01), pages 1546 - 1555, XP003017707
BELLINGHAUSEN I. ET AL.: "REGULATORY T CELLS GENERATED BY IL-10-TREATED DENDRITIC CELLS AND TGF-beta SUPPRESS TH2 IMMUNE RESPONSES IN ATOPIC INDIVIDUALS", IMMUNOBIOLOGY, vol. 210, no. 6-8, 2005, pages 571 + ABSTR. NO. V.8, XP003017708
BELLINGHAUSEN I. ET AL.: "INDUCTION OF REGULATORY T CELLS IN ALLERGIC INDIVIDUALS BY IL-10-TREATED DENDRITIC CELLS TOGETHER WITH TGF-beta", J. INVEST. DERMATOL., vol. 125, no. 3, 2005, pages A50 + ABSTR. NO. 292, XP003017709
ISHII Y.: "Translational Research no Genjo to Tenbo Men'eki Seigyo Saibo ni yoru Allergy Chiryo", BIOTHERAPY, vol. 20, no. 5, September 2006 (2006-09-01), pages 500 - 503, XP003017710
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (Kamiya-cho MT Bldg. 19F, 3-20 Toranomon 4-chome, Minato-k, Tokyo 01, 1050001, JP)
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