Title:
IMMUNO-ONCOLOGY THERAPEUTIC COMPOSITION USING ADJUVANT INCLUDING LIPOPEPTIDES AND POLY (I:C)
Document Type and Number:
WIPO Patent Application WO/2022/250416
Kind Code:
A1
Abstract:
An immuno-oncology therapeutic composition containing, as an active ingredient, an adjuvant including lipopeptides and poly (I:C) provided in one aspect of the present invention can induce a large therapeutic effect on a variety of carcinomas, and can be effectively used for anticancer therapy by significantly enhancing anticancer effects through combined administration with conventional anticancer drugs, such as chemical anticancer drugs, anticancer vaccines, and immune checkpoint inhibitors, having different mechanisms.
Inventors:
YUM JUNG SUN (KR)
CHO JUNGKI (KR)
AHN BYUNG CHEOL (KR)
JEONG SOOKYUNG (KR)
HEO YOONKI (KR)
JEON HONG JAE (KR)
KIM CHAN (KR)
CHO JUNGKI (KR)
AHN BYUNG CHEOL (KR)
JEONG SOOKYUNG (KR)
HEO YOONKI (KR)
JEON HONG JAE (KR)
KIM CHAN (KR)
Application Number:
PCT/KR2022/007348
Publication Date:
December 01, 2022
Filing Date:
May 24, 2022
Export Citation:
Assignee:
CHA VACCINE RES INSTITUTE CO LTD (KR)
International Classes:
A61K39/39; A61K9/08; A61K31/704; A61K38/17; A61K39/00; A61K39/395; A61K45/06; A61P35/00
Foreign References:
| KR20140119362A | 2014-10-10 | |||
| KR100900837B1 | 2009-06-04 | |||
| KR20160055861A | 2016-05-18 | |||
| KR20190018998A | 2019-02-26 | |||
| KR20160068751A | 2016-06-15 | |||
| KR100900837B1 | 2009-06-04 | |||
| KR101501583B1 | 2015-03-12 |
Other References:
METZGER, J. ET AL.: "Synthesis of novel immunologically active tripalmitoyl-S-glycerylcysteinyllipopeptides as useful intermediates for immunogen preparations", INT. J. PEPTIDE PROTEIN RES., vol. 37, 1991, pages 46 - 57, XP000471627
ROUS, R. ET AL.: "poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive 11-12", INTERNATIONAL IMMUNOL., vol. 16, 2004, pages 767 - 773
CUI, Z.F. QUI: "Synthetic double stranded RNA poly I:C as a potent peptide vaccine adjuvant: Therapeutic activity against human cervical cancer in a rodent model", CANCER IMMUNOL. IMMUNOTHERAPY, vol. 16, 2005, pages 1 - 13
ROUS, R. ET AL.: "poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive 11-12", INTERNATIONAL IMMUNOL., vol. 16, 2004, pages 767 - 773
CUI, Z.F. QUI: "Synthetic double stranded RNA poly I:C as a potent peptide vaccine adjuvant: Therapeutic activity against human cervical cancer in a rodent model", CANCER IMMUNOL. IMMUNOTHERAPY, vol. 16, 2005, pages 1 - 13
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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