Title:
IMMUNOCHROMATOGRAPHIC DETECTION METHOD FOR MULTIDRUG-RESISTANT STAPHYLOCOCCUS AND DIAGNOSTIC KIT
Document Type and Number:
WIPO Patent Application WO/2007/069673
Kind Code:
A1
Abstract:
It is intended to provide an immunochromatographic detection device which detects PBP2’ specifically produced by a multidrug-resistant Staphylococcus bacterium by an immunochromatographic detection method sensitively, simply and rapidly and is capable of determining infection with a multidrug-resistant Staphylococcus, a diagnostic method using the detection device, and a diagnostic kit including the detection device. The invention is directed to the immunochromatographic detection device for detecting a multidrug-resistant Staphylococcus which includes a sample supply unit which supplies a sample solution which is assumed to contain a multidrug-resistant Staphylococcus or a solution which is assumed to contain PBP2’ released from a cell wall by a pretreatment of a sample onto a sheet-shaped solid-phase support, a labeling reagent unit which retains a labeling reagent in which an antibody specifically binding to PBP2’ is labeled spreadable on the solid-phase support, and a trapping reagent unit in which a trapping reagent capable of trapping a complex of PBP2’ and the labeling reagent by specifically binding to the complex is immobilized, and in which an amphoteric surfactant, an anionic surfactant and/or a nonionic surfactant is contained in the trapping reagent unit or in the solid-phase support upstream of the trapping reagent unit.
Inventors:
ITO HIROMI (JP)
Application Number:
PCT/JP2006/324905
Publication Date:
June 21, 2007
Filing Date:
December 14, 2006
Export Citation:
Assignee:
DENKA SEIKEN KK (JP)
ITO HIROMI (JP)
ITO HIROMI (JP)
International Classes:
G01N33/569; G01N33/531; G01N33/543
Domestic Patent References:
| WO2001057531A1 | 2001-08-09 | |||
| WO2005015217A1 | 2005-02-17 |
Foreign References:
| JPH1078382A | 1998-03-24 | |||
| JP3638731B2 | 2005-04-13 |
Other References:
See also references of EP 1970706A4
HIDEO IGARASHI: "Shinshu to meneki (Invasion and immunity", TSST-1, vol. 3, 1994, pages 3 - 10
UTSUI, Y.; YOKOTA, T.: "Role of an altered penicillin-binding protein in methicillin- and cephem- resistant Staphyloccus aureus.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 28, 1985, pages 397 - 403
HIDEO IGARASHI: "Shinshu to meneki (Invasion and immunity", TSST-1, vol. 3, 1994, pages 3 - 10
UTSUI, Y.; YOKOTA, T.: "Role of an altered penicillin-binding protein in methicillin- and cephem- resistant Staphyloccus aureus.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 28, 1985, pages 397 - 403
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chom, Minato-ku Tokyo 01, JP)
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