Title:
IMMUNOCONJUGATES COMPRISING POXVIRUS-DERIVED PEPTIDES AND ANTIBODIES AGAINST ANTIGEN-PRESENTING CELLS FOR SUBUNIT-BASED POXVIRUS VACCINES
Document Type and Number:
WIPO Patent Application WO/2011/056721
Kind Code:
A3
Abstract:
The present invention concerns methods and compositions for subunit-based vaccines for inducing immunity against poxvirus infections, such as smallpox. Preferred embodiments concern immunoconjugates comprising one or more subunit antigenic peptides attached to an antibody or fragment thereof that targets antigen-producing cells (APCs). More preferably, the antibody binds to HLA-DR and the antigenic peptide is from an immunomodulating factor, such as the viral IL-18 binding protein (vIL18BP). However, mixtures of antigenic peptides from different viral proteins may also be used. The vaccine is capable of inducing immunity against poxvirus without risk of disseminated infection in immunocompromised hosts or transmission to susceptible contacts.
Inventors:
TAYLOR ALICE P (US)
MAKABI-PANZU BOBY (US)
GOLDENBERG DAVID M (US)
MAKABI-PANZU BOBY (US)
GOLDENBERG DAVID M (US)
Application Number:
PCT/US2010/054668
Publication Date:
October 13, 2011
Filing Date:
October 29, 2010
Export Citation:
Assignee:
CT FOR MOLECULAR MEDICINE AND IMMUNOLOGY (US)
TAYLOR ALICE P (US)
MAKABI-PANZU BOBY (US)
GOLDENBERG DAVID M (US)
TAYLOR ALICE P (US)
MAKABI-PANZU BOBY (US)
GOLDENBERG DAVID M (US)
International Classes:
A61K39/275; A61K39/385; C07K1/10
Foreign References:
| US6291208B1 | 2001-09-18 | |||
| US7612180B2 | 2009-11-03 | |||
| US20090269365A1 | 2009-10-29 |
Other References:
KRUMM ET AL.: "Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18 -binding protein.", PROC NATL ACAD SCI USA, vol. 105, no. 52, 2008, pages 20711 - 20715, XP008157395
DATABASE GENBANK [online] 8 December 2008 (2008-12-08), "IL-18 binding protein [Variola virus].", XP008157392, Database accession no. 042049
VAN VLIET ET AL.: "Poxvirus proteomics and virus-host protein interactions.", MICROBIOL MOL BIOL REV., vol. 73, no. 4, December 2009 (2009-12-01), pages 730 - 749, XP008157390
MENG ET AL.: "Variola virus IL-18 binding protein interacts with three human IL-18 residues that are part of a binding site for human IL-18 receptor alpha subunit.", VIROLOGY, vol. 358, no. 1, 2007, pages 211 - 220, XP008157403
See also references of EP 2496256A4
DATABASE GENBANK [online] 8 December 2008 (2008-12-08), "IL-18 binding protein [Variola virus].", XP008157392, Database accession no. 042049
VAN VLIET ET AL.: "Poxvirus proteomics and virus-host protein interactions.", MICROBIOL MOL BIOL REV., vol. 73, no. 4, December 2009 (2009-12-01), pages 730 - 749, XP008157390
MENG ET AL.: "Variola virus IL-18 binding protein interacts with three human IL-18 residues that are part of a binding site for human IL-18 receptor alpha subunit.", VIROLOGY, vol. 358, no. 1, 2007, pages 211 - 220, XP008157403
See also references of EP 2496256A4
Attorney, Agent or Firm:
NAKASHIMA, Richard A. (Morris Plains, New Jersey, US)
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