Title:
IMMUNOCYTOKINE, PREPARATION FOR SAME, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/032116
Kind Code:
A1
Abstract:
Provided in the present invention is an immunocytokine of an antibody respectively fusing IL-15 and IL-15Ra on an antigen on the surface of a target cell, capable of effectively and specifically targeting a complex of IL-15 and IL-15Ra to a tumor microenvironment, activating relevant immune cells within or in the vicinity of a tumor, achieving the goal of specifically killing of the tumor, and at the same time, preventing immunotoxicity induced by the systemic hyperactivation of NK cells.
Inventors:
WANG FENG (CN)
ZHENG HUAYANG (CN)
ZHANG YUHAN (CN)
ZHENG HUAYANG (CN)
ZHANG YUHAN (CN)
Application Number:
PCT/CN2020/109986
Publication Date:
February 25, 2021
Filing Date:
August 19, 2020
Export Citation:
Assignee:
SHANGHAI YICHEN BIOMED CO LTD (CN)
International Classes:
C07K14/54; A61K39/00; A61P35/00; C07K14/715; C07K16/28; C07K19/00; C12N15/12; C12N15/63
Domestic Patent References:
| WO2015131994A1 | 2015-09-11 | |||
| WO2005085282A1 | 2005-09-15 | |||
| WO2011034605A2 | 2011-03-24 |
Foreign References:
| CA3039930A1 | 2018-04-19 |
Other References:
AXIANG WANG; LI TIEPENG; ZHANG FANG; WANG YAO; DU XUEXIANG; GAO QUANLI: "PD-S15 Fusion Protein Specifically Target PD-1 and Rapidly Expands NK/T Cells", CHINESE JOURNAL OF CANCER BIOTHERAPY, vol. 26, no. 4, 4 April 2019 (2019-04-04), pages 389 - 395, XP055684809, DOI: 10.3872/j.issn.1007-385x.2019.04.004
VANESSA KERMER; VOLKER BAUM; NORA HORNIG; ROLAND E KONTERMANN; DAFNE MÜLLER: "An Antibody Fusion Protein for Cancer Immunotherapy Mimicking IL-15 trans-Presentation at the Tumor Site", MOLECULAR CANCER, vol. 11, no. 6, 6 April 2012 (2012-04-06), pages 1279 - 1288, XP002683666, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-12-0019
VANESSA KERMER; VOLKER BAUM; NORA HORNIG; ROLAND E KONTERMANN; DAFNE MÜLLER: "Antibody-Cytokine fusion proteins : Applications in cancer therapy", HHS PUBLIC ACCESS AUTHOR MANUSCRIPT, vol. 8, no. 5, 1 May 2008 (2008-05-01), pages 1 - 42, XP055535112, ISSN: 1535-7163, DOI: :10.1517/14712598.8.5.609
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877 - 883
PADLAN, FASEB J., vol. 9, 1995, pages 133 - 139
MACCALLUM, J. MOL. BIOL., vol. 262, no. 5, 1996, pages 732 - 45
J.IMMUNOL, vol. 183, no. 6, 2009, pages 3598 - 607
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
STRUCTURE, vol. 2, 1994, pages 1121 - 1123
See also references of EP 4019536A4
VANESSA KERMER; VOLKER BAUM; NORA HORNIG; ROLAND E KONTERMANN; DAFNE MÜLLER: "An Antibody Fusion Protein for Cancer Immunotherapy Mimicking IL-15 trans-Presentation at the Tumor Site", MOLECULAR CANCER, vol. 11, no. 6, 6 April 2012 (2012-04-06), pages 1279 - 1288, XP002683666, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-12-0019
VANESSA KERMER; VOLKER BAUM; NORA HORNIG; ROLAND E KONTERMANN; DAFNE MÜLLER: "Antibody-Cytokine fusion proteins : Applications in cancer therapy", HHS PUBLIC ACCESS AUTHOR MANUSCRIPT, vol. 8, no. 5, 1 May 2008 (2008-05-01), pages 1 - 42, XP055535112, ISSN: 1535-7163, DOI: :10.1517/14712598.8.5.609
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877 - 883
PADLAN, FASEB J., vol. 9, 1995, pages 133 - 139
MACCALLUM, J. MOL. BIOL., vol. 262, no. 5, 1996, pages 732 - 45
J.IMMUNOL, vol. 183, no. 6, 2009, pages 3598 - 607
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
STRUCTURE, vol. 2, 1994, pages 1121 - 1123
See also references of EP 4019536A4
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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