Title:
IMMUNODYNAMIC COMPLEXES AND METHODS FOR USING AND PREPARING SUCH COMPLEXES
Document Type and Number:
WIPO Patent Application WO2006004588
Kind Code:
A3
Abstract:
The invention is directed to immunodynamic complexes that, in embodiments of the invention, are surprisingly antimicrobial and immunoactive. By "immunoactive," it is meant that such compositions are capable of modulating, stimulating and repairing the immune system. Moreover, in embodiments of the invention, an immunodynamic complex is capable of supporting, maintaining and/or enhancing the structure and function of the immune system. In addition, this invention is directed to a method for preparing and using such compositions. Embodiments of the immunodynamic complexes of this invention are prepared from lacteal secretions derived from ungulates, such as cows.
Inventors:
STOFF JESSE A (US)
BERGSMA DAVID L (US)
WILLETT HARRY ADON (US)
WEIGHNER PAUL JAMES (US)
WEIGHNER MARK JOSEPH (US)
BERGSMA DAVID L (US)
WILLETT HARRY ADON (US)
WEIGHNER PAUL JAMES (US)
WEIGHNER MARK JOSEPH (US)
Application Number:
PCT/US2005/015939
Publication Date:
May 26, 2006
Filing Date:
May 05, 2005
Export Citation:
Assignee:
SIXTY EIGHT L L C (US)
STOFF JESSE A (US)
BERGSMA DAVID L (US)
WILLETT HARRY ADON (US)
WEIGHNER PAUL JAMES (US)
WEIGHNER MARK JOSEPH (US)
STOFF JESSE A (US)
BERGSMA DAVID L (US)
WILLETT HARRY ADON (US)
WEIGHNER PAUL JAMES (US)
WEIGHNER MARK JOSEPH (US)
International Classes:
A61K39/00; A61K9/127; A61K9/20; A61K9/48; A61K35/20; A61K38/17; A61K38/19; A61K38/21; A61K39/02; A61K39/09; A61K39/12; A61K39/39; A61P31/00; A61P37/00
Domestic Patent References:
| WO2000011476A1 | 2000-03-02 |
Foreign References:
| US4402938A | 1983-09-06 | |||
| US20020044927A1 | 2002-04-18 | |||
| US4816563A | 1989-03-28 | |||
| DE19936035A1 | 2001-02-08 | |||
| EP1146119A1 | 2001-10-17 | |||
| EP1408106A1 | 2004-04-14 |
Other References:
WILSON G B ET AL: "DE NOVO INITIATION OF SPECIFIC CELL-MEDIATED IMMUNE RESPONSIVENESS IN CHICKENS BY TRANSFER FACTOR SPECIFIC IMMUNITY INDUCER OBTAINED FROM BOVINE COLOSTRUM AND MILK", ACTA VIROLOGICA, vol. 32, no. 1, 1988, pages 6 - 18, XP009058413, ISSN: 0001-723X
WAKEFIELD D ET AL: "THE ROLE OF CYTOKINES IN THE PATHOGENESIS OF INFLAMMATORY EYE DISEASE", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 4, no. 1, January 1992 (1992-01-01), pages 1 - 5, XP009045964, ISSN: 1043-4666
TUNZI CHRISTINA R ET AL: "beta-Defensin expression in human mammary gland epithelia", PEDIATRIC RESEARCH, vol. 48, no. 1, July 2000 (2000-07-01), pages 30 - 35, XP002360392, ISSN: 0031-3998
KOLB ANDREAS F: "Engineering immunity in the mammary gland.", JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA. APR 2002, vol. 7, no. 2, April 2002 (2002-04-01), pages 123 - 134, XP002360393, ISSN: 1083-3021
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 2004, ZHONG J ET AL: "Regulation of allogeneic cornea to CD69 expression on human peripheral blood T lymphocytes and its subsets in vitro", XP002369818, Database accession no. EMB-2005109456
WAKEFIELD D ET AL: "THE ROLE OF CYTOKINES IN THE PATHOGENESIS OF INFLAMMATORY EYE DISEASE", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 4, no. 1, January 1992 (1992-01-01), pages 1 - 5, XP009045964, ISSN: 1043-4666
TUNZI CHRISTINA R ET AL: "beta-Defensin expression in human mammary gland epithelia", PEDIATRIC RESEARCH, vol. 48, no. 1, July 2000 (2000-07-01), pages 30 - 35, XP002360392, ISSN: 0031-3998
KOLB ANDREAS F: "Engineering immunity in the mammary gland.", JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA. APR 2002, vol. 7, no. 2, April 2002 (2002-04-01), pages 123 - 134, XP002360393, ISSN: 1083-3021
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 2004, ZHONG J ET AL: "Regulation of allogeneic cornea to CD69 expression on human peripheral blood T lymphocytes and its subsets in vitro", XP002369818, Database accession no. EMB-2005109456
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