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Title:
IMMUNOFLUORESCENCE KIT FOR DETECTING E-CADHERIN EXPRESSION OF PERIPHERAL BLOOD CIRCULATING TUMOR CELLS OF PATIENT WITH PANCREATIC CANCER
Document Type and Number:
WIPO Patent Application WO/2022/001826
Kind Code:
A1
Abstract:
An immunofluorescence kit for detecting E-Cadherin expression of peripheral blood circulating tumor cells of a patient with pancreatic cancer, which falls within the field of molecular biology technology. Also disclosed is a kit for detecting E-Cadherin expression of peripheral blood circulating tumor cells from a patient with pancreatic cancer and a detection method. A membrane filter device is used to separate and obtain CTCs from peripheral blood of a patient with advanced or recurrent pancreatic cancer from whom a tissue sample cannot be obtained, and immunofluorescence technology is further applied to detect the E‑Cadherin expression of the CTCs. The detection method can detect the E‑Cadherin expression condition of a patient with advanced or recurrent pancreatic cancer without using a needle biopsy to obtain a tissue sample. The sampling process is a minimally invasive technology, which can realize real-time detection, can avoid false positive results caused by edge effects possibly generated during the staining process, has a good stability, reduces cell loss, and improves the accuracy of detection.

Inventors:
HAO JIHUI (CN)
LI SHENG (CN)
REN HE (CN)
Application Number:
PCT/CN2021/102099
Publication Date:
January 06, 2022
Filing Date:
June 24, 2021
Export Citation:
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Assignee:
TIANJIN MEDICAL UNIV CANCER INSTITUTE & HOSPITAL (CN)
International Classes:
G01N33/58; B01D29/05; G01N33/569; G01N33/574
Foreign References:
CN111638354A2020-09-08
CN105510600A2016-04-20
CN105606823A2016-05-25
CN105606824A2016-05-25
US4891319A1990-01-02
US20190192739A12019-06-27
CN107602691A2018-01-19
CN107142310A2017-09-08
CN106701762A2017-05-24
Attorney, Agent or Firm:
JINAN SPRING PATENT & TRADEMARK OFFICE (CN)
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