Title:
IMMUNOFLUORESCENT STAINING TECHNIQUE FOR URINE EXFOLIATED TUMOUR CELLS OF UROTHELIAL CARCINOMA
Document Type and Number:
WIPO Patent Application WO/2018/137515
Kind Code:
A1
Abstract:
Provided are an immunofluorescent staining reagent for urine exfoliated tumour cells of a urothelial carcinoma and an application thereof, comprising using the two proteins CK20 and CD44V6 as a set of markers and using an immunofluorescent method to identify urine exfoliated tumour cells in order to thereby detect a urothelial carcinoma.
Inventors:
HAN RAY (CN)
JIN BAIYE (CN)
CHEN ANQI (CN)
FU GUANGHOU (CN)
JIN BAIYE (CN)
CHEN ANQI (CN)
FU GUANGHOU (CN)
Application Number:
PCT/CN2018/072880
Publication Date:
August 02, 2018
Filing Date:
January 16, 2018
Export Citation:
Assignee:
RUI HAN ZHI XIN MEDICAL TECH JIASHAN CO LTD (CN)
International Classes:
G01N33/533; G01N33/574
Foreign References:
| CN106944163A | 2017-07-14 | |||
| CN106867867A | 2017-06-20 | |||
| CN103889556A | 2014-06-25 | |||
| CN104651315A | 2015-05-27 |
Other References:
EISSA, S.: "Comparison of CD 44 and cytokeratin 20 mRNA in voided urine samples as diagnostic tools for bladder cance r", CLINICAL BIOCHEMISTRY, vol. 41, 9 September 2008 (2008-09-09), pages 1335 - 1341, XP025613171, DOI: doi:10.1016/j.clinbiochem.2008.08.085
WEAVER.E.J.: "Expression of cytokeratin 20 and CD 44 protein in upper uri- nary tract transitional cell carcinoma:cytologic-histologic correlation", CLINICAL BIOCHEMISTRY, vol. 23, no. 5, 31 October 2001 (2001-10-31)
DESAI, S. ET AL.: "Relationship of Cytokeratin 20 and CD 44 Protein Expression with WHO/ISUP Grade in pTa and pTl Papillary Urothelial Neoplasia", MOD PATHOL, vol. 13, no. 12, 31 December 2000 (2000-12-31), XP055526091, DOI: doi:10.1038/modpathol.3880241
YIKILMAZ, T.N.: "Clinical Use of Tumor Markers for the Detection and Pro- gnosis of Bladder Carcinoma: A Comparison of CD 44, Cytokeratin 20 and Su- rvivin", UROLOGICAL ONCOLOGY, vol. 13, no. 3, 28 June 2016 (2016-06-28), pages 2677 - 2683, XP055526098
WEAVER.E.J.: "Expression of cytokeratin 20 and CD 44 protein in upper uri- nary tract transitional cell carcinoma:cytologic-histologic correlation", CLINICAL BIOCHEMISTRY, vol. 23, no. 5, 31 October 2001 (2001-10-31)
DESAI, S. ET AL.: "Relationship of Cytokeratin 20 and CD 44 Protein Expression with WHO/ISUP Grade in pTa and pTl Papillary Urothelial Neoplasia", MOD PATHOL, vol. 13, no. 12, 31 December 2000 (2000-12-31), XP055526091, DOI: doi:10.1038/modpathol.3880241
YIKILMAZ, T.N.: "Clinical Use of Tumor Markers for the Detection and Pro- gnosis of Bladder Carcinoma: A Comparison of CD 44, Cytokeratin 20 and Su- rvivin", UROLOGICAL ONCOLOGY, vol. 13, no. 3, 28 June 2016 (2016-06-28), pages 2677 - 2683, XP055526098
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
Download PDF:
Previous Patent: COMMUNICATION METHOD AND APPARATUS
Next Patent: METHOD AND APPARATUS FOR TRANSMITTING SIGNALS
Next Patent: METHOD AND APPARATUS FOR TRANSMITTING SIGNALS