Title:
IMMUNOGENIC COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2022/133255
Kind Code:
A3
Abstract:
Provided herein are glycan engineered SARS-CoV-2 RBD polypeptides, fusion polypeptides comprising thereof, and immunogenic compositions comprising thereof. Also provided are methods of administering the RBD polypeptide, fusion polypeptide or immunogenic composition to a subject to elicit an immune response. Also provided are polynucleotides encoding the fusion polypeptide, and methods of administering a composition comprising the polynucleotide to a subject to elicit an immune response. In some embodiments, the polynucleotide is an RNA comprising modified ribonucleotides.
Inventors:
SCHIEF WILLIAM (US)
SCHIFFNER TORBEN (US)
STEICHEN JON (US)
HU XIAOZHEN (US)
SCHIFFNER TORBEN (US)
STEICHEN JON (US)
HU XIAOZHEN (US)
Application Number:
PCT/US2021/064100
Publication Date:
July 21, 2022
Filing Date:
December 17, 2021
Export Citation:
Assignee:
SCRIPPS RESEARCH INST (US)
International Classes:
C07K14/005; G01N33/569; G01N33/571
Foreign References:
| EP3715847A1 | 2020-09-30 | |||
| US20200009244A1 | 2020-01-09 |
Attorney, Agent or Firm:
GASZNER, Miklos (US)
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