Title:
IMMUNOGENIC COMPOUNDS FOR TREATMENT OF FIBROSIS, AUTOIMMUNE DISEASES AND INFLAMMATION
Document Type and Number:
WIPO Patent Application WO/2019/197563
Kind Code:
A3
Abstract:
The present invention relates to antigen-based immunotherapy targeting interleukin 13 receptor alpha 2 (I LI 3RA2) for prevention and/or treatment of fibrosis, an autoimmune disease and/or an inflammatory disease. In particular, the present invention provides the use of a (poly)peptide comprising an epitope of IL13RA2 or a sequence variant thereof for prevention and/or treatment of fibrosis, an autoimmune disease and/or an inflammatory disease. Moreover, the present invention also provides an immunogenic compound, a nanoparticle and a pharmaceutical composition comprising such a (poly)peptide and a nucleic acid encoding such a (poly)peptide for use in prevention and/or treatment of fibrosis, an autoimmune disease and/or an inflammatory disease.
Inventors:
CHENE LAURENT (FR)
BONNY CHRISTOPHE (FR)
STROZZI FRANCESCO (FR)
BONNY CHRISTOPHE (FR)
STROZZI FRANCESCO (FR)
Application Number:
PCT/EP2019/059319
Publication Date:
January 16, 2020
Filing Date:
April 11, 2019
Export Citation:
Assignee:
ENTEROME S A (FR)
International Classes:
A61K38/17; A61P29/00; C07K14/715; C07K16/28
Domestic Patent References:
| WO2014088432A1 | 2014-06-12 | |||
| WO2014089375A1 | 2014-06-12 | |||
| WO2013142477A1 | 2013-09-26 | |||
| WO2019072871A2 | 2019-04-18 | |||
| WO2013173411A1 | 2013-11-21 | |||
| WO2012027379A2 | 2012-03-01 | |||
| WO2006034334A2 | 2006-03-30 |
Foreign References:
| US20070087411A1 | 2007-04-19 |
Other References:
EGUCHI JUNICHI ET AL: "Identification of interleukin-13 receptor alpha2 peptide analogues capable of inducing improved antiglioma CTL responses", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 66, no. 11, 1 June 2006 (2006-06-01), pages 5883 - 5891, XP002768180, ISSN: 0008-5472
ANDREWS ET AL: "IL-13 receptor @a 2: A regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts", JOURNAL OF ALLERGY AND CLINICAL IMMUNO, ELSEVIER, AMSTERDAM, NL, vol. 118, no. 4, 1 October 2006 (2006-10-01), pages 858 - 865, XP005685904, ISSN: 0091-6749, DOI: 10.1016/J.JACI.2006.06.041
ANDREWS ET AL: "IL-13 receptor @a 2: A regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts", JOURNAL OF ALLERGY AND CLINICAL IMMUNO, ELSEVIER, AMSTERDAM, NL, vol. 118, no. 4, 1 October 2006 (2006-10-01), pages 858 - 865, XP005685904, ISSN: 0091-6749, DOI: 10.1016/J.JACI.2006.06.041
Attorney, Agent or Firm:
VON STOSCH, Andreas et al. (DE)
Download PDF:
Previous Patent: IMPROVED APPARATUS FOR REACTION AND INJECTION MOLDING
Next Patent: MCOPPB FOR USE AS MEDICAMENT
Next Patent: MCOPPB FOR USE AS MEDICAMENT