Title:
IMMUNOGLOBULIN-BINDING MODIFIED PROTEIN
Document Type and Number:
WIPO Patent Application WO/2017/022759
Kind Code:
A1
Abstract:
The present invention provides an antibody-binding protein having improved culture productivity in a genetic recombinant. The present invention relates to a protein that comprises two or more amino acid sequences derived from the E, D, A, B, or C domains of the protein A indicated in SED ID Nos. 1-5, that is obtained by substituting an amino acid residue corresponding to position 4 and/or position 7 of the C domain of an amino acid sequence derived from the domain furthest to the N-terminal side with an amino acid residue other than Arg, and in which the culture productivity in a genetic recombinant is improved compared to prior to the aforementioned substitution.
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Inventors:
NISHIHACHIJYO MASAKATSU (JP)
YAMASHITA KEITA (JP)
ODAWARA OSAMU (JP)
TSUCHIDATE TAKEYUKI (JP)
TAKANO MASAYUKI (JP)
YOSHIDA SHINICHI (JP)
YAMASHITA KEITA (JP)
ODAWARA OSAMU (JP)
TSUCHIDATE TAKEYUKI (JP)
TAKANO MASAYUKI (JP)
YOSHIDA SHINICHI (JP)
Application Number:
PCT/JP2016/072649
Publication Date:
February 09, 2017
Filing Date:
August 02, 2016
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C12N15/09; C07K1/22; C07K14/31; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Domestic Patent References:
| WO2014046278A1 | 2014-03-27 | |||
| WO2015005859A1 | 2015-01-15 |
Foreign References:
| JP2010504754A | 2010-02-18 | |||
| JP2006304633A | 2006-11-09 | |||
| JP2015077152A | 2015-04-23 |
Other References:
See also references of EP 3333262A4
Attorney, Agent or Firm:
YASUTOMI & ASSOCIATES (JP)
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