Title:
IMMUNOGLOBULIN-BINDING PEPTIDE WITH IMPROVED STABILITY
Document Type and Number:
WIPO Patent Application WO/2018/180204
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a novel modified protein G which is capable of binding to immunoglobulin and shows a high chemical stability against an alkali solution; an affinity separation matrix comprising the modified protein G as a ligand; and a method for producing an antibody or antibody fragment using the affinity separation matrix. The immunoglobulin-binding peptide according to the present invention is characterized by comprising an amino acid sequence derived by specifically mutating an amino acid sequence which exhaustively contains amino acid residues common to antibody-binding domains derived from wild type SpG.
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Inventors:
YOSHIDA SHINICHI (JP)
Application Number:
PCT/JP2018/008050
Publication Date:
October 04, 2018
Filing Date:
March 02, 2018
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C12N15/31; B01D15/38; B01J20/24; B01J20/28; B01J20/281; B01J20/34; C07K1/22; C07K14/315; C07K17/06; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63
Domestic Patent References:
| WO2016136910A1 | 2016-09-01 | |||
| WO2015030094A1 | 2015-03-05 | |||
| WO2016061427A1 | 2016-04-21 | |||
| WO1997026930A1 | 1997-07-31 |
Foreign References:
| JP2016079153A | 2016-05-16 | |||
| JPS63503032A | 1988-11-10 | |||
| JP2009195184A | 2009-09-03 | |||
| JP2016079153A | 2016-05-16 | |||
| JP2003088381A | 2003-03-25 | |||
| JP2017071908A | 2017-04-13 |
Other References:
PALMER, BENJAMIN ET AL.: "Design of stability at extreme alkaline pH in streptococcal protein G", JOURNAL OF BIOTECHNOLOGY, vol. 134, 2008, pages 222 - 230, XP022587995
GULICH, SUSANNE ET AL.: "Engineering streptococcal protein G for increased alkaline stability", PROTEIN ENGINEERING, vol. 15, no. 10, 2002, pages 835 - 842, XP055556696
HOBER S. ET AL., J. CHROMATOGR. B, vol. 848, 2007, pages 40 - 47
SHUKLA A. A. ET AL., TRENDS BIOTECHNOL., vol. 28, 2010, pages 253 - 261
BOUVET P. J. ET AL., INT. J. IMMUNOPHARMAC, vol. 16, 1994, pages 419 - 424
DERRICK J. P. ET AL., NATURE, vol. 359, 1992, pages 752 - 754
BAILEY L. ET AL., J. IMMUNOL. METHODS, vol. 415, 2014, pages 24 - 30
LINHULT M. ET AL., PROTEINS, vol. 55, 2004, pages 407 - 416
GULICH S. ET AL., PROTEIN ENG., vol. 15, 2002, pages 835 - 842
PALMER B. ET AL., J. BIOTECHNOL., vol. 134, 2008, pages 222 - 230
AKERSTROM ET AL., J. BIOL. CHEM., vol. 28, 1987, pages 13388
FAHNESTOCK ET AL., J. BACTERIOL., vol. 167, 1986, pages 870
NAGATA ET AL.: "Real-Time Analysis Experimental Method for Interaction Between Biological Substances", 1998, SPRINGER-VERLAG, pages: 41
GULICH, SUSANNE ET AL.: "Engineering streptococcal protein G for increased alkaline stability", PROTEIN ENGINEERING, vol. 15, no. 10, 2002, pages 835 - 842, XP055556696
HOBER S. ET AL., J. CHROMATOGR. B, vol. 848, 2007, pages 40 - 47
SHUKLA A. A. ET AL., TRENDS BIOTECHNOL., vol. 28, 2010, pages 253 - 261
BOUVET P. J. ET AL., INT. J. IMMUNOPHARMAC, vol. 16, 1994, pages 419 - 424
DERRICK J. P. ET AL., NATURE, vol. 359, 1992, pages 752 - 754
BAILEY L. ET AL., J. IMMUNOL. METHODS, vol. 415, 2014, pages 24 - 30
LINHULT M. ET AL., PROTEINS, vol. 55, 2004, pages 407 - 416
GULICH S. ET AL., PROTEIN ENG., vol. 15, 2002, pages 835 - 842
PALMER B. ET AL., J. BIOTECHNOL., vol. 134, 2008, pages 222 - 230
AKERSTROM ET AL., J. BIOL. CHEM., vol. 28, 1987, pages 13388
FAHNESTOCK ET AL., J. BACTERIOL., vol. 167, 1986, pages 870
NAGATA ET AL.: "Real-Time Analysis Experimental Method for Interaction Between Biological Substances", 1998, SPRINGER-VERLAG, pages: 41
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (JP)
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