Title:
IMMUNOHISTOCHEMICAL METHODS
Document Type and Number:
WIPO Patent Application WO2005044794
Kind Code:
A3
Abstract:
The present invention relates to immunohistochemical methods to identify biomarkers. This invention relates to the use of phospho-ERK (pERK) levels in tumor cells as a biomarker for a Raf kinase inhibitor. The invention also provides methods and compositions for diagnostic assays for detecting cancer.
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Inventors:
TAYLOR IAN (US)
WILHELM SCOTT (US)
WILHELM SCOTT (US)
Application Number:
PCT/US2004/036977
Publication Date:
September 21, 2006
Filing Date:
November 04, 2004
Export Citation:
Assignee:
BAYER PHARMACEUTICALS CORP (US)
TAYLOR IAN (US)
WILHELM SCOTT (US)
TAYLOR IAN (US)
WILHELM SCOTT (US)
International Classes:
G01N33/48; G01N33/574; C07D
Other References:
JERGENSEN ET AL.: "Expression of Activated Extracellular Signal-Regulated kinases 1/2 in Malignant Melanomas: Relationship with Clinical Outcome", CLINICAL CANCER RESEARCH, vol. 9, no. 14, 1 November 2003 (2003-11-01), pages 5325 - 5331, XP003005791
TANIMURA ET AL.: "Specific blockade of th ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44", BIOCHEMICAL AND BIPHYSICAL RESEARCH COMMUNICATIONS, vol. 304, no. 4, 16 May 2003 (2003-05-16), pages 801 - 806, XP003005792
ADEYINKA ET AL.: "Activated Mitogen-activated Protein Kinase Expression during Human Breast Tumorigenesis and Breast Cancer Progression", CLINICAL CANCER RESEARCH, vol. 8, no. 6, June 2002 (2002-06-01), pages 1747 - 1753, XP003005793
FU ET AL.: "Effects of Raf-Kinase Inhibitor Protein Expression on Suppression of Prostae Cancer Metastasis", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 95, 18 June 2003 (2003-06-18), pages 878 - 879, XP003005794
See also references of EP 1682512A4
TANIMURA ET AL.: "Specific blockade of th ERK pathway inhibits the invasiveness of tumor cells: down-regulation of matrix metalloproteinase-3/-9/-14 and CD44", BIOCHEMICAL AND BIPHYSICAL RESEARCH COMMUNICATIONS, vol. 304, no. 4, 16 May 2003 (2003-05-16), pages 801 - 806, XP003005792
ADEYINKA ET AL.: "Activated Mitogen-activated Protein Kinase Expression during Human Breast Tumorigenesis and Breast Cancer Progression", CLINICAL CANCER RESEARCH, vol. 8, no. 6, June 2002 (2002-06-01), pages 1747 - 1753, XP003005793
FU ET AL.: "Effects of Raf-Kinase Inhibitor Protein Expression on Suppression of Prostae Cancer Metastasis", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 95, 18 June 2003 (2003-06-18), pages 878 - 879, XP003005794
See also references of EP 1682512A4
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