Title:
IMMUNOLOGICAL MEASUREMENT DEVICE AND IMMUNOLOGICAL MEASUREMENT METHOD
Document Type and Number:
WIPO Patent Application WO/2017/033296
Kind Code:
A1
Abstract:
An immunological measurement device characterized by being provided with: a first compartment into which a reactive particle solution and a sample are introduced, wherein the reactive particle solution contains reactive particles each modified with a substance capable of causing an antigen-antibody reaction with a substance of interest and has electrical conductivity; a second compartment into which a liquid having electrical conductivity is introduced; a measurement vessel which has a volume smaller than a volume of a reaction solution, i.e., a solution containing the reactive particle solution and the sample, per one reaction particle, and which has a narrow hole through which the first compartment and the second compartment are connected to each other; a first electrode which is arranged inside the first compartment; a second electrode which is arranged inside the second compartment; a voltage source which can apply a voltage between the first electrode and the second electrode; a measurement section which measures a current or electric resistance flowing between the first electrode and the second electrode; a pulse signal detection section which detects the change in pulse of the current or the electric resistance measured in the measurement section; and a calculation processing section which compiles pulse signals detected by the pulse detection section within a predetermined time, calculates a percentage of aggregation of the reactive particles, and calculates the quantity of the substance of interest in the sample on the basis of the resultant percentage of aggregation.
Inventors:
TAKAKURA TATSUKI (JP)
KOHARA YOSHINOBU (JP)
KOHARA YOSHINOBU (JP)
Application Number:
PCT/JP2015/073927
Publication Date:
March 02, 2017
Filing Date:
August 26, 2015
Export Citation:
Assignee:
HITACHI LTD (JP)
International Classes:
G01N33/543
Foreign References:
| JPS5480411A | 1979-06-27 | |||
| JPH07128217A | 1995-05-19 | |||
| JP2005257536A | 2005-09-22 |
Other References:
HAN Y ET AL.: "Label-free biomarker assay in a microresistive pulse sensor via immunoaggregation.", ANAL CHEM., vol. 86, no. 19, pages 9717 - 9722, XP055365683
Attorney, Agent or Firm:
TODA Yuji (JP)
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