Title:
IMMUNOLOGICAL MEASUREMENT REAGENT FOR USE IN MEASUREMENT OF KL-6
Document Type and Number:
WIPO Patent Application WO/2011/001999
Kind Code:
A1
Abstract:
Disclosed are a measurement reagent and a measurement method both for accurately measuring KL-6, particularly a measurement reagent and a measurement method for accurately measuring KL-6 in a sample that contains a rheumatoid factor and/or a non-specific substance other than the rheumatoid factor.
Specifically disclosed is an immunological measurement reagent which comprises a solution containing a rheumatoid factor interference inhibitor and having a pH value of 4.0 to 5.5 and a solution containing an insoluble carrier, wherein an anti-KL-6 antibody is supported on the insoluble carrier. The use of the immunological measurement reagent enables the accurate measurement of KL-6 in a sample that contains a rheumatoid factor and/or a non-specific substance other than the rheumatoid factor.
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Inventors:
KONDOU JUNICHI (JP)
YAMAMOTO MITSUAKI (JP)
KANEKO CHIE (JP)
YAMAMOTO MITSUAKI (JP)
KANEKO CHIE (JP)
Application Number:
PCT/JP2010/061109
Publication Date:
January 06, 2011
Filing Date:
June 30, 2010
Export Citation:
Assignee:
SEKISUI MEDICAL CO LTD (JP)
SANKO JUNYAKU KK (JP)
KONDOU JUNICHI (JP)
YAMAMOTO MITSUAKI (JP)
KANEKO CHIE (JP)
SANKO JUNYAKU KK (JP)
KONDOU JUNICHI (JP)
YAMAMOTO MITSUAKI (JP)
KANEKO CHIE (JP)
International Classes:
G01N33/53; G01N33/543
Foreign References:
| JP2005121441A | 2005-05-12 | |||
| JPH0731207B2 | 1995-04-10 | |||
| JPH0731207B2 | 1995-04-10 | |||
| JP2005121441A | 2005-05-12 | |||
| JP4083855B2 | 2008-04-30 | |||
| JP2006308576A | 2006-11-09 | |||
| JPH0712818A | 1995-01-17 |
Other References:
OHSHIMO ET AL.: "KL-6, a human MUC1 mucin, promotes proliferation and survival of lung fibroblasts.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 338, 2005, pages 1845 - 1852, XP027218372
See also references of EP 2450709A4
KOHNO N, KYOIZUMI S, AWAYA Y, FUKUHARA H, YAMAKIDO M, AKIYAMA M., CHEST., vol. 96, no. 1, July 1989 (1989-07-01), pages 68 - 73
DEYO RA, POPE RM, PERSELLIN RH, J RHEUMATOL., vol. 7, no. 3, May 1980 (1980-05-01), pages 279 - 87
KOHLER G, MILSTEIN C., EUR J IMMUNOL., vol. 6, no. 7, July 1976 (1976-07-01), pages 511 - 9
See also references of EP 2450709A4
KOHNO N, KYOIZUMI S, AWAYA Y, FUKUHARA H, YAMAKIDO M, AKIYAMA M., CHEST., vol. 96, no. 1, July 1989 (1989-07-01), pages 68 - 73
DEYO RA, POPE RM, PERSELLIN RH, J RHEUMATOL., vol. 7, no. 3, May 1980 (1980-05-01), pages 279 - 87
KOHLER G, MILSTEIN C., EUR J IMMUNOL., vol. 6, no. 7, July 1976 (1976-07-01), pages 511 - 9
Attorney, Agent or Firm:
MOEGI PATENT OFFICE (JP)
Patent business corporation It burns and is ぎ特許事務所. (JP)
Patent business corporation It burns and is ぎ特許事務所. (JP)
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