Title:
IMMUNOMODULATING SAPONINS, A METHOD FOR THEIR PREPARATION AND THEIR USE FOR VACCINES
Document Type and Number:
WIPO Patent Application WO2003040163
Kind Code:
A3
Abstract:
The present invention relates to new saponins for increasing the immune response in mammals and finds application in the field of immunology, supplying in particular new adjuvants, obtained by hemi-synthesis, starting from terpene sources. It also embraces the methods for the use of the new saponins as adjuvants to increase the immune response to an antigen in a mammal. The saponins of the present invention are suitable for veterinary and human pharmaceutical compositions which include one or more antigens, in particular those of synthetic origin, and one or more diluents, in pharmaceutically acceptable vehicles. These compositions can be used as immunopotenciators and/or immunomodulators in animals and human beings. The present invention further constitutes a vaccination method that includes the administration of one or more antigens and one or optionally more than one hemi-synthetic saponin of the invention.
Inventors:
COSTA MARIA (PT)
GREEN LUKE (GB)
SCHMIDT RICHARD (DE)
LEY STEVE (GB)
ELEUTERIO MARIA (PT)
ALVES SUSANA (PT)
RUBALCAVA CONCEPCION (ES)
GREEN LUKE (GB)
SCHMIDT RICHARD (DE)
LEY STEVE (GB)
ELEUTERIO MARIA (PT)
ALVES SUSANA (PT)
RUBALCAVA CONCEPCION (ES)
Application Number:
PCT/PT2002/000016
Publication Date:
November 27, 2003
Filing Date:
November 07, 2002
Export Citation:
Assignee:
INST NAC DE ENGENHARIA E TECNO (PT)
UNIV CAMBRIDGE TECH (GB)
COSTA MARIA (PT)
GREEN LUKE (GB)
SCHMIDT RICHARD (DE)
LEY STEVE (GB)
ELEUTERIO MARIA (PT)
ALVES SUSANA (PT)
RUBALCAVA CONCEPCION (ES)
CARDOSO FERNANDO (PT)
UNIV CAMBRIDGE TECH (GB)
COSTA MARIA (PT)
GREEN LUKE (GB)
SCHMIDT RICHARD (DE)
LEY STEVE (GB)
ELEUTERIO MARIA (PT)
ALVES SUSANA (PT)
RUBALCAVA CONCEPCION (ES)
CARDOSO FERNANDO (PT)
International Classes:
A61P37/04; C07J69/00; (IPC1-7): C07J69/00; A61P37/04; C07H15/256
Domestic Patent References:
| WO1996038161A1 | 1996-12-05 |
Other References:
SO H S ET AL: "Effect of a novel saponin adjuvant derived from Quillaja saponaria on the immune response to recombinant hepatitis B surface antigen", MOLECULAR AND CELLS, KOREAN SOCIETY FOR MOLECULAR SOCIETY, KR, vol. 7, no. 2, 1997, pages 178 - 186, XP002128520
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 11 28 November 1997 (1997-11-28)
LIU, ZIMIN ET AL: "Triterpenoid saponins from Gypsophila oldhamiana.", JOURNAL OF NATURAL PRODUCTS (1995), 58(10), 1632-5, XP009016344
KIM, YOUN CHUL ET AL: "Application of hydrothermolysis to the studies of the constituents of the Merck Saponin", LIEBIGS ANNALEN DER CHEMIE (1992), (9), 941-6, XP001154522
NIE, RUILIN ET AL: "Saponins from Chinese medicinal plants. (I). Isolation and structures o hemslosides", PLANTA MEDICA (1984), 50(4), 322-7, XP009016334
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 11 28 November 1997 (1997-11-28)
LIU, ZIMIN ET AL: "Triterpenoid saponins from Gypsophila oldhamiana.", JOURNAL OF NATURAL PRODUCTS (1995), 58(10), 1632-5, XP009016344
KIM, YOUN CHUL ET AL: "Application of hydrothermolysis to the studies of the constituents of the Merck Saponin", LIEBIGS ANNALEN DER CHEMIE (1992), (9), 941-6, XP001154522
NIE, RUILIN ET AL: "Saponins from Chinese medicinal plants. (I). Isolation and structures o hemslosides", PLANTA MEDICA (1984), 50(4), 322-7, XP009016334
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