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Title:
IMMUNOMODULATOR
Document Type and Number:
WIPO Patent Application WO/2019/134705
Kind Code:
A1
Abstract:
Disclosed are an immunomodulatory agent, and in particular an activating STING compound and uses thereof acting as an immunomodulatory agent in preparing a drug. Also disclosed is/are a compound represented by formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, a prodrug thereof, or uses of a metabolite in preparing an STING-activating drug, and providing a new option for clinical screening and/or preparation of a drug for treating STING-associated diseases. (I)

Inventors:
LI, Jin (Building 6, No. 8 Huigu 1st East Road,Tianfu International Bio-Town, Shuangliu Distric, Chengdu Sichuan 0, 610200, CN)
ZHANG, Dengyou (Building 6, No. 8 Huigu 1st East Road,Tianfu International Bio-Town, Shuangliu Distric, Chengdu Sichuan 0, 610200, CN)
WEI, Yonggang (Building 6, No. 8 Huigu 1st East Road,Tianfu International Bio-Town, Shuangliu Distric, Chengdu Sichuan 0, 610200, CN)
PAN, Fei (Building 6, No. 8 Huigu 1st East Road,Tianfu International Bio-Town, Shuangliu Distric, Chengdu Sichuan 0, 610200, CN)
MA, Rong (Building 6, No. 8 Huigu 1st East Road,Tianfu International Bio-Town, Shuangliu Distric, Chengdu Sichuan 0, 610200, CN)
LI, Yingfei (Building 6, No. 8 Huigu 1st East Road,Tianfu International Bio-Town, Shuangliu Distric, Chengdu Sichuan 0, 610200, CN)
LI, Si (Building 6, No. 8 Huigu 1st East Road,Tianfu International Bio-Town, Shuangliu Distric, Chengdu Sichuan 0, 610200, CN)
ZHANG, Yi (Building 6, No. 8 Huigu 1st East Road,Tianfu International Bio-Town, Shuangliu Distric, Chengdu Sichuan 0, 610200, CN)
CHEN, Wei (Building 6, No. 8 Huigu 1st East Road,Tianfu International Bio-Town, Shuangliu Distric, Chengdu Sichuan 0, 610200, CN)
Application Number:
CN2019/070743
Publication Date:
July 11, 2019
Filing Date:
January 08, 2019
Export Citation:
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Assignee:
HITGEN INC. (Building 6, No. 8 Huigu 1st East Road,Tianfu International Bio-Town, Shuangliu Distric, Chengdu Sichuan 0, 610200, CN)
International Classes:
C07D405/14; A61K31/4184; A61K31/4188; A61P31/00; A61P35/00; A61P37/00; C07D403/14; C07D487/04
Domestic Patent References:
WO2017175147A12017-10-12
WO2017175156A12017-10-12
Foreign References:
CN107108684A2017-08-29
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (The Yiguanmiao Post Office Box A-42, Hi-Tech ZoneChengdu, Sichuan 1, 610041, CN)
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