Title:
IMMUNOMODULATOR
Document Type and Number:
WIPO Patent Application WO/2021/027729
Kind Code:
A1
Abstract:
The present invention relates to an immunomodulator, in particular, to a compound as represented by formula I, or a stereoisomer thereof, a pharmaceutically acceptable salt thereof. Experiments show that the compound has good IL-17A inhibitory activity, can be used for preparing an IL-17A inhibitor and a drug for preventing and/or treating a IL-17A-mediated disease (such as an inflammation, an autoimmune disease, an infectious disease, a cancer, and a precancerous syndrome), and provides a new medicinal possibility for clinical treatment of a disease related to IL-17A activity abnormality.
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Inventors:
LI JIN (CN)
ZHANG DENGYOU (CN)
BAI XIAOGUANG (CN)
SHANG SIYUN (CN)
HONG XINFU (CN)
ZHONG MENG (CN)
LIU LI (CN)
ZHOU XIANSI (CN)
YANG DANMEI (CN)
HUANG HAOLAN (CN)
LIN YANPING (CN)
CHEN XIN (CN)
ZHANG DENGYOU (CN)
BAI XIAOGUANG (CN)
SHANG SIYUN (CN)
HONG XINFU (CN)
ZHONG MENG (CN)
LIU LI (CN)
ZHOU XIANSI (CN)
YANG DANMEI (CN)
HUANG HAOLAN (CN)
LIN YANPING (CN)
CHEN XIN (CN)
Application Number:
PCT/CN2020/107845
Publication Date:
February 18, 2021
Filing Date:
August 07, 2020
Export Citation:
Assignee:
HITGEN INC (CN)
International Classes:
C07D403/12; A61K31/4184; A61P1/00; A61P1/16; A61P3/10; A61P9/10; A61P11/06; A61P13/10; A61P13/12; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P37/02; C07D235/14
Domestic Patent References:
| WO2014066726A2 | 2014-05-01 | |||
| WO2013116682A1 | 2013-08-08 |
Foreign References:
| CN110511213A | 2019-11-29 | |||
| CN108299256A | 2018-07-20 | |||
| CN103459385A | 2013-12-18 | |||
| CN105601617A | 2016-05-25 | |||
| CN104069102A | 2014-10-01 |
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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