Title:
IMMUNOPOTENTIATING COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2004/004771
Kind Code:
A1
Abstract:
Compositions for treating cancer or infectious diseases mediated by immunopotentiation which is caused by inhibiting a immunosuppressive signal induced by PD-1, PD-L1 or PD-L2; a therapeutic method using the same; methods of screening an immunopotentiator, an anticancer substance or a substance against infectious diseases contained in these compositions as the active ingredient; a cell line to be used in these screening methods; a method of evaluating an anticancer agent; and a mammal having cancer cells transplanted therein which is to be used in the evaluation. The above compositions inhibiting the function of PD-1, PD-L1 or PD-L2 are useful in treating cancer or infectious diseases.
Inventors:
HONJO TASUKU (JP)
MINATO NAGAHIRO (JP)
IWAI YOSHIKO (JP)
SHIBAYAMA SHIRO (JP)
MINATO NAGAHIRO (JP)
IWAI YOSHIKO (JP)
SHIBAYAMA SHIRO (JP)
Application Number:
PCT/JP2003/008420
Publication Date:
January 15, 2004
Filing Date:
July 02, 2003
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
HONJO TASUKU (JP)
MINATO NAGAHIRO (JP)
IWAI YOSHIKO (JP)
SHIBAYAMA SHIRO (JP)
HONJO TASUKU (JP)
MINATO NAGAHIRO (JP)
IWAI YOSHIKO (JP)
SHIBAYAMA SHIRO (JP)
International Classes:
A61K31/7088; A61K35/14; A61K39/395; A61P31/00; A61P35/00; A61P35/04; A61P37/04; C07K16/42; C12N15/02; C12P21/08; C12Q1/02; G01N33/50; G01N33/574; (IPC1-7): A61K45/00; A61K38/17; A61K39/395; A61K31/7088; A61P31/00; A61P35/00; A61P35/04; A61P37/04; C12N5/10; C12Q1/02; G01N33/50; A61K6/027
Domestic Patent References:
| WO2001014557A1 | 2001-03-01 | |||
| WO2002000730A2 | 2002-01-03 | |||
| WO2002000692A2 | 2002-01-03 | |||
| WO2003042402A2 | 2003-05-22 | |||
| WO2003011911A1 | 2003-02-13 | |||
| WO2002078731A1 | 2002-10-10 |
Foreign References:
| EP0670369A2 | 1995-09-06 |
Other References:
BROWN JULIA A. ET AL.: "Blockade of PD-1 ligands on dendritic cells enhances T cell activation and cytokine production", FASEB JOURNAL, vol. 16, no. 4, March 2002 (2002-03-01), pages A710, 517.4, XP002973917
BROWN JULIA A. ET AL.: "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production", THE JOURNAL OF IMMUNOLOGY, vol. 170, no. 3, February 2003 (2003-02-01), pages 1257 - 1266, XP002973918
See also references of EP 1537878A4
BROWN JULIA A. ET AL.: "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production", THE JOURNAL OF IMMUNOLOGY, vol. 170, no. 3, February 2003 (2003-02-01), pages 1257 - 1266, XP002973918
See also references of EP 1537878A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Horiguchi No.2 Bldg. 7F 2-6,
Nihonbashi-Ningyocho, 2-chom, Chuo-ku Tokyo, JP)
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