Title:
IMMUNOPOTENTIATOR, CELL-MEDIATED IMMUNOPOTENTIATOR, AND T CELL PROLIFERATION AGENT
Document Type and Number:
WIPO Patent Application WO/2016/076276
Kind Code:
A1
Abstract:
An immunopotentiator including a collagen peptide that has an average molecular weight of 2,000-12,000. Immunity can be elevated, taking as an indicator an immunity score comprising the sum of the scores assigned to following seven parameters when a score of 1 (low immunity), 2 (medium immunity), or 3 (high immunity) on a scale of three established in advance in correspondence with levels of immunity is assigned to the measured values of each of the seven parameters: T cell count, CD8-positive CD28-positive T cell count, CD4-positive T cell/CD8-positive T cell ratio, naïve T cell count, naïve T cell/memory T cell ratio, B cell count, and NK cell count.
Inventors:
KOYAMA YOH-ICHI (JP)
KUWABA KUMIKO (JP)
HAYASHIDA OSAMU (JP)
KUSUBATA MASASHI (JP)
KUWABA KUMIKO (JP)
HAYASHIDA OSAMU (JP)
KUSUBATA MASASHI (JP)
Application Number:
PCT/JP2015/081509
Publication Date:
May 19, 2016
Filing Date:
November 09, 2015
Export Citation:
Assignee:
NIPPI INC (JP)
International Classes:
A61K38/17; A61K38/00; A61P37/04; A61P43/00
Foreign References:
| JPH09255588A | 1997-09-30 | |||
| JP2012116773A | 2012-06-21 | |||
| JPH07278012A | 1995-10-24 | |||
| JP2000201649A | 2000-07-25 |
Other References:
CHETOUI N ET AL.: "Collagen type I-mediated activation of ERK/MAP Kinase is dependent on Ras, Raf-1 and protein phosphatase 2A in Jurkat T cells", MOLECULAR IMMUNOLOGY, vol. 43, no. 10, 2006, pages 1687 - 1693
WARRINGTON KJ ET AL.: "Characterisation of the immune response to type I collagen in scleroderma", ARTHRITIS RES THER, vol. 8, no. 4, 2006, pages R136
KOYAMA Y ET AL.: "Supplemental Ingestion of Collagen Peptide Improves T- cell -related Human Immune Status - Placebo-controlled Double-blind Study", JPN PHARMACOL THER(BASIC PHARMACOLOGY & THERAPEUTICS, vol. 43, no. 1, 2015, pages 51 - 56
WARRINGTON KJ ET AL.: "Characterisation of the immune response to type I collagen in scleroderma", ARTHRITIS RES THER, vol. 8, no. 4, 2006, pages R136
KOYAMA Y ET AL.: "Supplemental Ingestion of Collagen Peptide Improves T- cell -related Human Immune Status - Placebo-controlled Double-blind Study", JPN PHARMACOL THER(BASIC PHARMACOLOGY & THERAPEUTICS, vol. 43, no. 1, 2015, pages 51 - 56
Attorney, Agent or Firm:
KIMURA MITSURU (JP)
Mitsuru Kimura (JP)
Mitsuru Kimura (JP)
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