Title:
IMMUNOREGULATORY METHOD, NUCLEIC ACID COMPOSITION FOR IMMUNOREGULATION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/033124
Kind Code:
A1
Abstract:
Provided is a polynucleotide from which a cell or extracellular vesicle capable of satisfactorily activating antigen-specific T cells can be produced. Provided is a polynucleotide containing at least one sequence selected from the group consisting of: (a) a sequence encoding a fusion protein (A) including an antigen-presenting MHC molecule and capable of presenting the antigen-presenting MHC molecule on the outside of the membrane of a cell or extracellular vesicle; (b) a sequence encoding a fusion protein (B) including at least one T cell stimulating cytokine or a subunit thereof and capable of presenting the T cell stimulating cytokine on the outside of the membrane of a cell or extracellular vesicle; (c) a sequence encoding a fusion protein (C) including a T cell co-stimulatory molecule and capable of presenting the T cell co-stimulatory molecule on the outside of the membrane of a cell or extracellular vesicle; (d) a sequence encoding a fusion protein (D) including an antigen-presenting MHC molecule and at least one T cell stimulating cytokine or a subunit thereof and capable of presenting the antigen and the T cell stimulating cytokine on the outside of the membrane of a cell or extracellular vesicle; and (e) a sequence encoding a fusion protein (E) including an antigen-presenting MHC molecule, at least one T cell stimulating cytokine or a subunit thereof, and a T cell co-stimulatory molecule and capable of presenting the antigen, the T cell stimulating cytokine, and the T cell co-stimulatory molecule on the outside of the membrane of a cell or extracellular vesicle.
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Inventors:
HANAYAMA RIKINARI (JP)
YAMANO TOMOYOSHI (JP)
MATOBA KAZUTAKA (JP)
YAMANO TOMOYOSHI (JP)
MATOBA KAZUTAKA (JP)
Application Number:
PCT/JP2022/033026
Publication Date:
March 09, 2023
Filing Date:
September 01, 2022
Export Citation:
Assignee:
UNIV NAT CORP KANAZAWA (JP)
NISSAN CHEMICAL CORP (JP)
NISSAN CHEMICAL CORP (JP)
International Classes:
C12N15/62; A61K31/7088; A61K36/06; A61K48/00; A61P31/00; A61P35/00; A61P37/02; A61P37/08; C07K14/47; C07K14/495; C07K14/54; C07K14/55; C07K14/74; C07K19/00; C12N15/12; C12N15/19; C12N15/24; C12N15/26; C12N15/63
Domestic Patent References:
| WO2021172595A1 | 2021-09-02 | |||
| WO2021172596A1 | 2021-09-02 |
Foreign References:
| JP2021502122A | 2021-01-28 | |||
| JP2020534809A | 2020-12-03 | |||
| JP2020534864A | 2020-12-03 | |||
| JP2021507682A | 2021-02-25 | |||
| US20200071668A1 | 2020-03-05 | |||
| JP2021506304A | 2021-02-22 | |||
| JP2016520518A | 2016-07-14 |
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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