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Title:
IMMUNOSTIMULATING AGENT AND METHOD FOR PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/099997
Kind Code:
A1
Abstract:
The object is to provide: a safe immunostimulating agent which can be used as a pharmaceutical or a food material; a method for production of the immunostimulating agent; and a novel application of a coffee extract residue. Disclosed is an immunostimulating agent comprising a coffee extract as an active ingredient. Preferably, the coffee extract is an extract containing arabinogalactan. The immunostimulating effect of the immunostimulating agent relies on the promotion of the proliferation of an immunocompetent cell such as a macrophage. The immunocompetent cell is preferably any one selected from a macrophage-like strain RAW264 or J774.1, a murine splenic cell, a murine peritoneal macrophage and a murine dendritic cell. A composition containing the immunostimulating agent can be used as a composition such as a pharmaceutical composition, a food composition and a cosmetic composition.

Inventors:
TAKAGI, Michihiro (7-20-101, Mukoyama 1-chome Takarazuka-sh, Hyogo 05, 6650005, JP)
高木 道浩 (〒05 兵庫県宝塚市武庫山1丁目7番20-101 Hyogo, 6650005, JP)
IWAI, Kazuya (LTD. R & D Center 3-1-4, Zushi, Takatsuki-sh, Osaka 36, 5690036, JP)
岩井 和也 (〒36 大阪府高槻市辻子3-1-4 ユ-シ-シ-上島珈琲株式会社 R&Dセンター内 Osaka, 5690036, JP)
UEDA, Takemi (LTD. R & D Center 3-1-4, Zushi, Takatsuki-sh, Osaka 36, 5690036, JP)
Application Number:
JP2007/053747
Publication Date:
September 07, 2007
Filing Date:
February 28, 2007
Export Citation:
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Assignee:
UCC UESHIMA COFFEE CO., LTD. (1-6 Tamondori 5-chome, Chuo-ku Kobe-sh, Hyogo 15, 6500015, JP)
ユ-シ-シ-上島珈琲株式会社 (〒15 兵庫県神戸市中央区多門通5丁目1蕃6号 Hyogo, 6500015, JP)
TAKAGI, Michihiro (7-20-101, Mukoyama 1-chome Takarazuka-sh, Hyogo 05, 6650005, JP)
高木 道浩 (〒05 兵庫県宝塚市武庫山1丁目7番20-101 Hyogo, 6650005, JP)
IWAI, Kazuya (LTD. R & D Center 3-1-4, Zushi, Takatsuki-sh, Osaka 36, 5690036, JP)
岩井 和也 (〒36 大阪府高槻市辻子3-1-4 ユ-シ-シ-上島珈琲株式会社 R&Dセンター内 Osaka, 5690036, JP)
International Classes:
A61K36/74; A23F5/28; A23L1/30; A61K31/715; A61P37/04; A61P43/00
Foreign References:
JP2004051582A2004-02-19
JP2005008616A2005-01-13
JPS6028401A1985-02-13
JPH04190765A1992-07-09
JPS5215894A1977-02-05
Other References:
PENG X. ET AL.: 'Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from Lycium barbarum L' CHINESE JOURNAL OF CHEMISTRY vol. 19, no. 12, 2001, pages 1190 - 1197, XP003017702
REDGWELL R.J. ET AL.: 'Effect of roasting on degradation and structural features of polysaccharides in Arabica coffee beans' CARBOHYDR. RES. vol. 337, no. 5, 2002, pages 421 - 431, XP004349733
'Igaku Daijiten', vol. 17TH ED., 1990, NANZANDO CO., LTD. page 1610, XP003017703
'Seikagaku Jiten', vol. 3RD ED., 1998, KABUSHIKI KAISHA TOKYO KAGAKU DOJIN page 685, XP003017704
NUNES F.M. ET AL.: 'Chemical characterization of the high molecular weight material extracted with hot water from green and roasted arabica coffee' J. AGRIC. FOOD CHEM. vol. 49, no. 4, 2001, pages 1773 - 1782, XP002334077
OOSTERVELD A. ET AL.: 'Extraction and characterization of polysaccharides from green and roasted Coffea arabica beans' CARBOHYDRATE POLYMER vol. 52, no. 3, 2003, pages 285 - 296, XP004410358
Attorney, Agent or Firm:
OGURA, Keishichi (2-25, Kowakae 4-chome Higashiosaka-sh, Osaka 18, 5770818, JP)
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