Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
IMMUNOSTIMULATING AGENT
Document Type and Number:
WIPO Patent Application WO/2007/100151
Kind Code:
A1
Abstract:
[PROBLEMS] To provide an immunostimulating agent capable of imparting a potent chemotactic activity to a leukocyte such as a macrophage. [MEANS FOR SOLVING PROBLEMS] A solution containing a pulverized "mekabu" (sporophyll of "wakame seaweed" (Undaria pinnatifida)) component is treated with an enzyme to hydrolyze a protein contained in the solution. The solution is then centrifuged to extract a supernatant fraction, thereby a polysaccharide extract solution can be prepared. The polysaccharide extract solution is centrifuged to extract a precipitate fraction. The precipitate fraction is further separated into four fractions A, B, C and D in accordance with elution peaks by anion exchange chromatography. Among these fractions, fraction D which has the highest anionic degree is extracted.

Inventors:
TSUTSUURA, Yuka (MaizonreveCC#103, 4-6-12 hanamihigash, koga-shi Fukuoka, 811-3112, JP)
Application Number:
JP2007/054597
Publication Date:
September 07, 2007
Filing Date:
March 02, 2007
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
MAWATARI, Shouji (4-26-11, morooka hakata-k, fukuoka-shi Fukuoka, 816-0094, JP)
馬渡 祥二 (〒94 福岡県福岡市博多区諸岡4-26-11 Fukuoka, 816-0094, JP)
TSUTSUURA, Koukichi (2-50-306, gokusyomachi hakata-k, fukuoka-shi Fukuoka, 812-0037, JP)
International Classes:
A61K36/02; A61K31/737; A61P37/02
Foreign References:
JP3876271B1
JP2001181303A
JP2002265370A
JPH0253731A
Other References:
IIZUKA M.: 'Mekabu Fucoidan no Kinosei' NEW FOOD IND. vol. 47, no. 9, 2005, pages 1 - 7, XP003017048
OFUSA T.: 'Kaiyo Shigen Wakame Mekabu no Fucoidan -Ko Gan.Ko Virus Sayo no Katsuyo-' FOOD RESEARCH no. 607, 01 January 2006, pages 61 - 63, XP003017049
HIROKO M. ET AL.: 'Antitumor activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida' IN VIVO vol. 17, no. 3, 2003, pages 245 - 249, XP003017050
NAGUMO T. ET AL.: 'Separation of sulfated, fucose -containing polysaccharides from the brown seaweed Sargassum kjellmanianum and their heterogeneity and antitumor activity' KITASATO ARCHIVES OF EXPERIMENTAL MEDICINE vol. 61, no. 1, 1988, pages 59 - 67, XP003017051
Attorney, Agent or Firm:
TSURUWAKA, Toshio (Nishi-shinjuku House #512, 4-29-4 nishi-shinjuk, shinjuku-ku Tokyo, 160-0023, JP)
Download PDF: