Title:
IMMUNOTOXIN CONJUGATES FOR USE IN THERAPY
Document Type and Number:
WIPO Patent Application WO/2019/121687
Kind Code:
A3
Abstract:
The present invention relates to conjugates comprising an immunotoxin linked to a therapeutic agent, wherein said immunotoxin comprises a binding domain fused to an adenosine diphosphate (ADP) ribosylating toxin, pharmaceutical compositions comprising said conjugates, and methods for the preparation of said immunotoxins.
Inventors:
MÜLLER FABIAN (DE)
Application Number:
PCT/EP2018/085503
Publication Date:
September 06, 2019
Filing Date:
December 18, 2018
Export Citation:
Assignee:
UNIV FRIEDRICH ALEXANDER ER (DE)
International Classes:
A61K47/55; A61K47/68; A61P35/00; A61P37/02
Domestic Patent References:
| WO2009032954A1 | 2009-03-12 |
Other References:
KAZUNORI ISHIGE ET AL: "Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma", INTERNATIONAL JOURNAL OF CANCER, vol. 123, no. 12, 15 December 2008 (2008-12-15), US, pages 2915 - 2922, XP055479232, ISSN: 0020-7136, DOI: 10.1002/ijc.23865
FABIAN MÜLLER: "Synergistic immunotoxin-paclitaxel combination against lymphoma", AGING (ALBANY, NY), vol. 9, no. 6, 13 June 2017 (2017-06-13), US, pages 1471 - 1472, XP055479193, ISSN: 1945-4589, DOI: 10.18632/aging.101251
X. LIU ET AL: "Protein Kinase Inhibitor H89 Enhances the Activity of Pseudomonas Exotoxin A-Based Immunotoxins", MOLECULAR CANCER THERAPEUTICS, vol. 15, no. 5, 1 May 2016 (2016-05-01), pages 1053 - 1062, XP055478890, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-15-0828
FABIAN MÜLLER: "Synergistic immunotoxin-paclitaxel combination against lymphoma", AGING (ALBANY, NY), vol. 9, no. 6, 13 June 2017 (2017-06-13), US, pages 1471 - 1472, XP055479193, ISSN: 1945-4589, DOI: 10.18632/aging.101251
X. LIU ET AL: "Protein Kinase Inhibitor H89 Enhances the Activity of Pseudomonas Exotoxin A-Based Immunotoxins", MOLECULAR CANCER THERAPEUTICS, vol. 15, no. 5, 1 May 2016 (2016-05-01), pages 1053 - 1062, XP055478890, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-15-0828
Attorney, Agent or Firm:
SCHIWECK, Wolfram et al. (DE)
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