Title:
IMPROVED ALPHA-V BETA-8 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2015/195835
Kind Code:
A3
Abstract:
Provided herein are antibodies specific for integrin αvβ8 that change the conformation of β8 so that, upon binding, the ability of αvβ8 to induce release of active, mature TGFβ peptide is inhibited.
Inventors:
NISHIMURA STEPHEN (US)
LOU JIANLONG (US)
CORMIER ANTHONY (US)
BARON JODY LYNN (US)
MARKS JAMES D (US)
MURRAY LYNNE (GB)
TSUI PING (US)
WU YANLI (US)
LOU JIANLONG (US)
CORMIER ANTHONY (US)
BARON JODY LYNN (US)
MARKS JAMES D (US)
MURRAY LYNNE (GB)
TSUI PING (US)
WU YANLI (US)
Application Number:
PCT/US2015/036284
Publication Date:
March 10, 2016
Filing Date:
June 17, 2015
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
MEDIMMUNE LLC (US)
MEDIMMUNE LTD (GB)
MEDIMMUNE LLC (US)
MEDIMMUNE LTD (GB)
International Classes:
A61K39/395
Domestic Patent References:
| WO2013026004A2 | 2013-02-21 |
Foreign References:
| US20120058128A1 | 2012-03-08 |
Other References:
MINAWAGA, S ET AL.: "Selective Targeting Of TGF-Beta Activation To Treat Fibroinflammatory Airway Disease.", SCI TRANSL MED., vol. 6, no. 241, 18 June 2014 (2014-06-18), pages 241ra79, XP009182474, DOI: doi:10.1126/scitranslmed.3008074
Attorney, Agent or Firm:
HAANES, Elizabeth J. et al. (St. Louis, Missouri, US)
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