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Title:
IMPROVED GELLED OXYGEN PRODUCTS
Document Type and Number:
WIPO Patent Application WO/1998/053836
Kind Code:
A1
Abstract:
The present invention relates to consumer products such as a gel product containing active oxygen and optionally colostrum for application to the skin to provide oxygen and optionally additional nutrient by the colostrum. The oxygen is in the form of stable activated oxygen in an amount of between 0.1 to as high as 35 % and is in addition to the amount of oxygen normally dissolved in water. The active oxygen is dispersed in a suitable carrier which includes water and provides a firm non-flowing gel, the latter including an aqueous viscosity increasing agent and a pH adjusting agent, the pH of the product being in the range of 6.8 to 7.2. The product may also include processed colostrum which also provides antibacteriostatic properties and other beneficial properties.

Inventors:
ANDERSON MICHAEL R (US)
Application Number:
PCT/US1998/009402
Publication Date:
December 03, 1998
Filing Date:
May 05, 1998
Export Citation:
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Assignee:
ANDERSON MICHAEL R (US)
International Classes:
A61K8/22; A61K8/98; A61K35/20; A61K36/185; A61K36/258; A61K36/28; A61K36/48; A61K36/53; A61K36/534; A61K36/61; A61K36/71; A61K36/82; A61K36/886; A61K36/899; A61Q1/02; A61Q5/02; A61Q5/12; A61Q11/00; A61Q15/00; A61Q19/00; A61Q19/10; (IPC1-7): A61K35/20
Domestic Patent References:
WO1994016675A11994-08-04
WO1995000155A11995-01-05
Foreign References:
EP0334776A21989-09-27
US5556481A1996-09-17
US5147548A1992-09-15
Other References:
"AERATION.", NALCO WATER HANDBOOK, XX, XX, 1 January 1979 (1979-01-01), XX, pages 16.01 - 16.09., XP002910367
Attorney, Agent or Firm:
Pavitt, William H. (Suite 330 100 Corporate Point, Culver City CA, US)
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Claims:
CLAIMS What is claimed as being new and therefore desired to be protected is as follows: Claim
1. A consumer product for application to a person's skin, comprising: a suitable carrier material including water and forming a self standing gel and containing as an essential ingredient an effective amount of stable active oxygen in the range of between 0.1% and 35% by weight over an above the amount of oxygen normally dissolved in water at standard temperature and pressure, said product having a pH in the range of between 6.8 and 7.2.
2. Claim.
3. A consumer product as set forth in claim 1 wherein further including processed colostrum.
4. Claim.
5. A consumer product as set forth in claim 1 wherein said carrier includes a pH adjusting agent and an aqueous viscosity increasing agent.
6. Claim.
7. A consumer product as set forth in claim 1 wherein said water containing said stable activated oxygen further includes dissolved oxygen, sodium chloride, essential minerals and trace minerals.
8. Claim.
9. A consumer product as set forth in claim 2 wherein said processed colostrum includes at least 5% water and not less than 55% protein with 27% being immunoglobulins and fat in an amount not to exceed 14%.
10. Claim.
11. A consumer product as set forth in claim 2 wherein said processed colostrum is present in an amount of between 0.5% and 5.0% by weight.
12. Claim.
13. A consumer product as set forth in claim 1 wherein said carrier includes a pH adjusting agent and an aqueous viscosity increasing agent, and wherein the water containing said stable activated oxygen includes diatomic oxygen, dissolved oxygen, sodium chloride, essential minerals and trace minerals, said stable activated oxygen being present in an amount of between 0.1% and 25.0 % by weight.
14. Claim.
15. A consumer product as set forth in claim 1 wherein said product further includes processed colostrum and wherein said carrier includes a pH adjusting agent and an aqueous viscosity increasing agent, and wherein said stable activated oxygen includes diatomic oxygen, sodium chloride, essential minerals and trace minerals.
16. Claim.
17. A consumer product as set forth in claim 8 wherein said processed colostrum is present in an amount of between 0.5% and 5% by weight.
18. Claim.
19. A consumer product as set forth in claim 2 wherein said carrier includes a pH adjusting agent and an aqueous viscosity increasing agent.
Description:
IMPROVED GELLED OXYGEN PRODUCTS Field of Invention This invention relates to products containing active oxygen, more particularly to improved consumer products such as cosmetics and the like which contain stable activated oxygen, far in excess of the amount of oxygen dissolved in water and which may optionally include colostrum and which provide many benefits in terms of bacteriostatic action and rapid adsorption into the body through the skin and/or membranes such as the mucous membranes.

Background of the Invention It is reported that the principal reason for premature aging of the facial skin is that the subcutaneous cell tissue, which should regularly receive oxygen and nutrients by fluid exchange between blood plasma and interstitial fluid, receives inadequate amounts of these nutrients and oxygen. It is generally believed that for the skin to maintain its youthful appearance, the biological process should be given assistance in compensating for the deficit of oxygen and nutrients.

It is also the case that there are no blood vessels in the outer layer of the skin.

Capillaries are responsible for providing nutrients and oxygen. Unfortunately, circulation in these capillaries declines as one grows older. The capillaries tend to become less permeable so less oxygen and nutrients pass from the capillaries to the extracellular fluid which surrounds the cells. Typically reduced oxygen and nutrients manifests itself in the epidermal layers as dry, wrinkled skin, wrinkled, lined, blotchy, less elastic, and thus the skin looks less healthy. It is also the case that water at normal temperatures and pressure

contains dissolved oxygen in an amount of about 9.5 mg/L or 0.00095% by weight, i.e., 950 ppm which is the equivalent of 0.95 grams/L.

Colostrum is a lactation product produced by the mother after birth (parturition) of mammals such as humans and cows. It is reported and recognized that the nursing newborn receives antibodies from the mother and which are present in colostrum during early feeding after birth Blanc. B., 1981; Biochemical aspects of human milk-comparison with bovine milk; World Rev. Nutr. Diet. 36: 1-89. Typically, the term colostrum milk is used to designate the mammal milk produced for about 5 to 7 days after parturition.

Colostrum is yellow in color since the concentration of catenoids is high, as much as ten times that of mature milk (that produced about 21-22 days after parturition). It is also known that colostrum has higher protein and mineral content as compared to mature milk: it is also lower in fat and lactose content than mature milk.

It is reported (Blanc, supra) that the percentage of protein in bovine colostrum is about twice that of human colostrum. This source of natural protein is an attractive aspect of colostrum or products made from colostrum. Further, bovine colostrum contains about 50% of a somatic cell known as polymorphonuclear leukocytes. Human colostrum contains mainly mononuclear leukocytes.

Medical researchers have been attracted to colostrum because of the immunological aspects. Colostrum is known to contain a number of leukocytes, immunoglobulins and lysozymes The typical immunoglobulins include IgA, IgD, IgE, IgG and IgM, with IgG being the most abundant. The literature also reports that the immunological effect of colostrum milk is reduced due to the hostile character of the stomach, see: Roos et al, 1995, "1SN-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine", Journal of Nutrition, 125(5): 123844, May. Earlier, it had been reported that the main antibody in milk, IgA, functions on mucosal membranes such as the mouth, throat, nasal, lungs, eyes, rectum etc. to prevent infection from the outside, see: Hanson, Lars A. et al, 1998, "Antiviral and Antibacterial

Factors in Human milk", in Lars A. Hanson, ed. Biology of Human Milk, Nestle Nutrition Workshop Series, Vol. 15, Raven Press, New York. Thus, colostrum is recognized as having antibacterial activity, in part due to the presence of lactoferrin in bovine colostrum, see U.S. Patent 4,342,747. Also present in colostrum are enzymes such as lactoperoxidase-thiocyanate plus peroxidase and zanthine oxidase which oxidize bacteria by generating and releasing hydrogen peroxide.

It is known that several products include various forms of colostrum, for example U.S. Patents 5,147,548 of September 15, 1992 and 5,556,481 of September 17, 1996.

EPO publication 334 775 B 1 describes the use of serum colostrum in a cosmetic or pharmaceutical composition. PCT publication WO 94/16675 of August 4, 1994 describes a cosmetic or pharmaceutical composition containing equine colostrum, while PCT publication WO 95/00155 of January 5, 1995 describes a wound healing composition which includes a colostrum fraction. None of these patent or publications describe the use of stable activated oxygen.

It is also known to attempt to provide hydrogen peroxide in consumer products due to the strong oxidizer nature of hydrogen peroxide with the resultant antibacterial activity of hydrogen peroxide. However, hydrogen peroxide is a powerful oxidizer and is generally considered unstable and readily oxidizes any oxidizable material with which it contacts. For example, hydrogen peroxide is unstable in the presence of light and/or heat.

Since most consumer products which contain hydrogen peroxide are intended to deliver the peroxide to the skin or teeth, for example, care must be taken to assure activity of the peroxide over the useful life of the product. For this reason, some consumer products which contain hydrogen peroxide, the latter forming hydrogen and oxygen on decomposition, are packaged so that the hydrogen peroxide is kept separate from other components which are oxidized by the peroxide, the packaging is somewhat complex dual dispenser packaging. It is also the case that hydrogen peroxide does not have a long shelf life and quickly decomposes so as to lose its effectiveness. Typically, products containing

hydrogen peroxide are packaged in opaque packages such as dark glass bottles or opaque oxidation resistant tubes and containers in order to increase the shelf life of the peroxide.

The reactivity of hydrogen peroxide virtually precludes use of transparent packaging materials such as clear glass or tinted glass or clear plastic containers.

While colostrum has some antibacterial properties and acts as a nutrient, those properties can be enhanced naturally by incorporation of a source of oxygen into any colostrum product intended for use topically as contrasted to ingestion. However, the use of hydrogen peroxide is not effective since the latter has a short shelf life and is highly reactive with various materials, even those with which it is admixed, especially if used in a strength sufficient to provide antibacterial properties for infectious agents or antigens such as bacteria, spores, fungus and the like. It is also the case that consumer products containing hydrogen peroxide are not pH balanced and are generally of a pH greater than about 8.0 in order to increase the stability of the peroxide in those cases where it is admixed in the container with the other components of the product.

One aspect of the present invention is the use of activated oxygen to increase the active oxygen content in water far above the amount of oxygen which can normally be dissolved in water. For example, at normal temperatures and pressure, the amount of dissolved oxygen in about 9.5 ml/L or 0.00095%, as mentioned. For certain types of products, especially cosmetic types of products the use of a relatively high amount of stable activated oxygen in the product has beneficial effects since it is believed to be absorbed through the skin and provided anti-bacterial, anti-viral and anti-fungal properties for safe and natural cleansing of the skin. The amount of stable activated oxygen which is present in the products of this invention far exceeds the amount of oxygen dissolved in water. Particular advantages accrue if the cosmetic product is in the form of a gel, preferably non-flowing, so that the latter tends to remain in place on the applied region of the skin surface.

Thus, it is an object of the present invention to provide an improved consumer product such as a body lotion, wrinkle eraser, night eye cream, face cream, preferably in the form of a gel, for example, and which contains a relatively high amount of stable activated oxygen and which may be adsorbed through the skin to provide at least some of the oxygen needed for healthy appearing skin.

It is another object of this invention to provide a consumer product of the type described which contains colostrum and stable activated oxygen, the combination acting as both nutrient and oxygen for healthy skin as well as having anti-bacterial, anti-viral and anti-fungal properties.

Yet another object of this invention is to provide a consumer product of the type described which contains colostrum and stable activated oxygen, each available from commercial suppliers, thus permitting compounding of the various products with relative ease and relatively simple packaging of the product.

Still another object of the present invention is the provision of a consumer product of the type described containing stable activated oxygen wherein the product has a relatively long shelf life and wherein all of the components may be admixed together rather than isolated in the packaging until mixed immediately before use and wherein the product may be pH balanced.

It is yet another object of this invention to provide a consumer product of the type described, for topical application rather than being ingested, which contains stable activated oxygen and wherein the activated oxygen enhances the bacteriostatic qualities of the colostrum.

Still another object of this invention is to provide a consumer product of the type described which includes stable activated oxygen and which may be pH stabilized.

Yet another object of this invention is to provide a novel and unique cosmetic product for application to human skin composed of an effective amount of stable active oxygen in a suitable carrier therefor, preferably a gel carrier.

Summary of the Invention The above and other objects of this invention are achieved by providing an improved consumer product of the type described containing stable activated oxygen in a suitable carrier and wherein the activated oxygen may be packaged together in admixed form with the carrier and wherein the product may optionally include colostrum. The carrier composition may vary widely depending upon the type and nature of the cosmetic product.

The use of stable activated oxygen in a consumer product for application to the skin has several advantages among which is the ability of the activated oxygen to act as an antimicrobial agent in the product thus precluding and/or retarding the growth of bacteria in the product as well as providing antimicrobial qualities when applied to the skin.

Another advantage of the use of stable activated oxygen is that the product may be pH balanced, especially for products intended to be applied to the skin. The stable activated oxygen also acts as bacteriostatic agent when applied topically to the skin. The single major advantage of stable activation oxygen is its ability to be readily absorbed into the skin, to supply oxygen for increasing the health of the skin.

Stable active oxygen is present in an amount of at least 0.1% and as high as 35% by weight of the total composition depending upon the specific composition, and preferably in the range of between 0.1% to 30% for products intended to supply oxygen to the skin, all by weight, and is sufficiently stable to be exposed to temperatures as high as 150 to 180 degrees F, a temperature well within that used in formulating the product and well within the ambient temperature to which the product may be exposed. The amount of stable active oxygen is that in excess of the amount of oxygen normally dissolved in water at normal temperatures and pressure. One of the advantages of the use of stable activated oxygen in the amounts herein set forth is the fact that no preservatives are needed in the product.

The amount of stable active oxygen may be determined by any one of several analytical techniques such as Method 421B ofthe Standard Methods for the Examination of Water and Waste Water and is the sodium azide modification of the method and approved by the EPA. Also useable are the Winkler method and the DPD method involving a color change as an indication of the amount of oxygen.

For formulations which are intended to provide additional nutrients as well as oxygen, processed colostrum may be used, as will be described. It is also understood that stable activated oxygen may be used in other consumer products, optionally with colostrum, as will also be described.

While the specification concludes with claims particularly pointing out and distinctly claiming the subject matter which is regarded as the invention, it is believed that the invention, the objects and features of the invention, and further objects, features and advantages thereof will be better understood from the following detailed description, it being understood that the same is illustrative of the invention and should not be construed in a limiting sense.

Detailed Description of the Invention While the consumer products to which this invention relates include roll-on deodorant, body wash, body lotion, shampoo, hair conditioner, wrinkle eraser, night eye cream, face cream, blending spray, tooth whitening sticks, mouthwash, tooth whitening gel and tooth polisher, for example, but is not limited thereto. The material of this invention relates principally to a gel formulation containing a substantial amount of stabilized active oxygen for supplying oxygen to the skin and thus improving the health and appearance of the skin, especially facial skin. Colostrum may be used with the activated oxygen where it is desired to provide added nutrients.

The active materials, stable activated oxygen and optionally processed colostrum, are in the form of a pH stabilized gel which includes at least one viscosity increasing agent

to provide a gel structure. It is understood that the active material may be dispersed in any suitable carrier which may vary widely depending on the type of consumer product above mentioned. In virtually all cases there is usually a small amount of water present and it is the water which contains stable activated oxygen, the latter basically in the form of diatomic oxygen. Also present in the water is a small amount of sodium chloride and trace minerals. The activated oxygen may be introduced into the composition by adding it in aqueous form to the deionized water which is generally present or by adding it separately. One commercially available product which contains between 400,000 and 10 parts per million of stable activated oxygen is available from BIO2 International, Inc. of San Luis Obispo California. As a general rule, the stable activated oxygen may be present in an amount of between 0.1% and 35%, by weight of the final composition, for some of the products disclosed. In the case of the gel formulations intended to supply oxygen, the stable active oxygen is present in the range of 0.1% to 25% by weight although greater or lesser amounts may be used. Again, the reference to stable active oxygen is to oxygen in excess of that normally present as dissolved oxygen in water.

When stable active oxygen is present in an amount of at least 20% by weight, preservatives are not needed.

As mentioned, the principal components of the commercially available stable activated oxygen material are distilled water, sodium chloride about 0.001% and trace minerals in the amount of0.001%. The amount of normally dissolved oxygen is about 9.5 mg/L (950 ppm) while the stable activated oxygen in the source material used to prepare the products of this invention is present in an amount of between 200,000 ppm to 400,000 ppm. The balance of the stable activated oxygen material is distilled water. The minerals include (based on one liter of product), calcium (23ng), chloride (2000ng), magnesium (16ng), phosphorous (SOng), potassium (0.lng), sodium (1600ng) and sulfur (13ng).

Also present are trace minerals such as chromium (3300ng), copper (0.04ng), cobalt

(lng), iodine (13100ng), iron (12.9ng), manganese (5ng), molybdenum (3ng), selenium (long), vanadium (25ng), and zinc (0.04ng).

The stable active oxygen is not dissolved in the distilled water but is present as diatomic oxygen which is unbound to any other molecule such as a salt or halogen molecule. This product is made by an electrolysis process in which the hydrogen gas is bubbled off but in which the oxygen remains as undissolved and in a stabilized condition.

The use of a stable activated oxygen material containing between 200,000 ppm and 400,000 ppm of stable activated oxygen is preferred for ease of shipment and safety, although it is to be understood that the stable active oxygen can be present in an amount far in excess of 400,000 ppm but care must be exercised in shipping and handling.

While stable activated oxygen is present in the product of this invention, one may also use other oxidants such as hydrogen peroxide, especially in tooth pastes, tooth whitening pastes or sticks. In the case of the gel products, due to the relatively high percentage of activated oxygen, other oxidants are not necessary. Since oxygen, in the form herein described, is so effective as a skin cleanser and in assisting in the metabolic growth of the skin, the use of other oxidants is normally not necessary.

In accordance with some forms of this invention, the product may also include colostrum so that the antimicrobial and antibacteriostatic effects of the stable activated oxygen are enhanced by the colostrum. It is also the case that the presence of stable activated oxygen enhances the beneficial effects of the colostrum. In the case of the gel products of this invention, the colostrum is used to provide nutrients to the skin and is thus present in those products which are intended to provide nutrients in addition to oxygen nutrient. In general, if present, colostrum is present in an amount of at least 0.05% and as much as 5% by weight ofthe composition, with the preferred amount being ofthe order of 1% by weight ofthe composition. A suitable commercial source of colostrum is a food grade colostrum available from Immuno-Dynamics, Inc., of Perry, Iowa. Typically, the colostrum is gathered from certified healthy cattle within 24 hours

after the birth of the second calf. The gathered colostrum is frozen for transportation to a USDA approved processing plant. At the plant it may be filtered for impurities, pasteurized, homogenized and gently spray dried at relatively low temperature to assure retention of biological activity. Typically, the processed colostrum product is a light tan fluffy powder, soluble in water and having a slightly toasty odor. As supplied, it contains about 5% water and not less than 55% protein with 27% being immunoglobulins; fat is present in an amount not to exceed 14%. The term "processed colostrum" thus refers to the natural colostrum which has been processed by reputable processors. A list of such processors is available from the Center for Bovine Colostrum Research located in Salt Lake City, Utah.

Since the processing of natural colostrum to produce a biologically active product, as above described, involves pasteurization which may result in dehydration of the enzymes present in natural colostrum with the result that the bacteriostatic character of processed biologically active colostrum is somewhat less than the native colostrum since the hydrogen peroxide forming enzymes have been removed or rendered at least partially inactive.

In accordance with this invention and in the case of colostrum containing products, the reduced content of hydrogen peroxide forming enzymes and thus the oxidizing character of the biologically active colostrum is compensated for by the use of an effective amount of stable activated oxygen. The result is that the final product contains the immunoglobulins and proteins of colostrum and the activated oxygen which promotes the antimicrobial quality of the product. In the case of the gels, the colostrum tends to enhance the antimicrobial properties of the mixture but also provides nutrient to the skin along with a substantial amount of stable activated oxygen. All of this is accomplished while providing a product with a stable shelf life, under normal storage conditions, since there is no decomposition or reduction in effectiveness of hydrogen peroxide due to heat and/or light. Moreover, the product may have the advantage of

being pH balanced, i.e., a pH of between 6.8 and 7.2 for products containing only stable active oxygen or those including the processed colostrum in addition to the stable active oxygen.

As noted, the stable and activated oxygen is supplied as an aqueous material containing between 200,000 and 400,000 parts per million of activated oxygen. In this form it is readily used in compounding and since the material is stable to about 150-180 degrees F, no major loss of activity is encountered during formulation into products, i.e., heating below about 180 degrees F does not adversely affect the active oxygen.

While material such as hydrogen peroxide are not needed with products of the present invention, at the lower percentages of stable activated oxygen in the final product, e.g., 0.1% to 0.5%, there may be formulations in which the peroxide may be used.

The carrier for the active ingredients which include stable active oxygen and optionally processed colostrum may be creams, sticks, lotions, ointments, liquids and gels.

Typical formulations of various products and descriptions of various carriers for the various products in accordance with this invention are as follows:

Gel Formula 1 Material Amount by percentage Diatomic oxygen (activated oxygen) 98.35 Carbomer 940 1.0 Triethanolamine 0.65 The effective amount of stable activated oxygen in this example is 29.5% by weight based on a source material containing 300,000 ppm of stable activated oxygen.

Gel Formula 2 Material Amount by percentage Diatomic oxygen (activated oxygen) 97.63 Carbomer 940 1.2 EMU oil 0.52 Sodium hydroxide 0.65 The effective amount of stable activated oxygen in this example is 229.28% by weight based on a source material containing 300,000 ppm of stable activated oxygen.

Gel Formula 3 Material Amount by percentage Diatomic oxygen (activated oxygen) 94.30 Xantham gum 1.5 Glycerin 3.0 Colostrum (processed) 1.20

The effective amount of stable activated oxygen in this example is 26.67% by weight based on a source material containing 300,000 ppm of stable activated oxygen.

The diatomic oxygen amount is expressed in terms of the amount of the aqueous composition containing 300,000 ppm of activated oxygen in distilled water, as already described, which is oxygen over and above the oxygen normally dissolved in water. All amounts are percentage by weight. It is to be understood that the amount of diatomic oxygen (activated oxygen) material in the above examples may be varied depending upon the amount of diatomic oxygen in the source material, i.e., 200,000 to 400,000 ppm. For lower percentages of stable active oxygen, the use of a source material of lower oxygen content may be used and diluted with distilled water.

In addition, the above compositions pH adjusters and aqueous viscosity increasing agents may be used. The pH is adjusted to between 6.8 to 7.2 by the addition of the pH adjusting materials. A sufficient amount of the aqueous viscosity increasing agent is also added so that the gel is sufficiently "stiff' to remain on the vertically oriented portions of the face and other skin surfaces, i.e., the gel does not flow when applied and is a firm self- standing gel. Typical aqueous viscosity increasing materials are those listed on page 99 of the CTFA Cosmetic Ingredient Handbook (First Edition) while the pH adjusters may be any of those set forth on page 77 of the same reference work (CTFA) and the same are incorporated herein by reference, as though fully set forth.

Fragrance Free Eve Cream Material Amount by percentage Hydrogenated Polyisobutene 12.00 Glycerine 8.00 Stearic Acid 4.00 Glyceryl Stearate SE 6.00

Cetyl Alcohol 1.65 PEG 40 Stearate 2.00 Soribitan tristearate 1.80 Myristyl Myristate 1.55 Petrolatum 1.50 Cyclomethionone 1.00 Hydrolyzed Soy Protein .050 Vitamin E acetate 0.20 Sodium PCA 0.18 Chamomile extract 0.16 Aloe vera gel 0.50 Trisodium EDTA 0.015 Sodium benzoate 0.01 Potassium sorbate 0.01 Methylparaben 0.10 Propylparaben 0.1 Imidazolidlnyl 0.20 Processed colostrum 0.013 Stabilized oxygen 0.20 Water to 100%

Moisturizing Cream Phase Material Amount by percentage A Deionized water 77.12 A Methylparaben 0.150 A Polawax 2.100 A Allantion 0.50 A Glycerine 0.750 A Diazolidynl urea 0.110 B Cetyl alcohol 2.70 B Stearyl alcohol 2.800 B Lecithin 0.500 B Soybean oil 6.00 B Wheat germ oil 5.00 B Cyclomethicone 1.00 B Propylparaben 0.125 C Processed Colostrum 1.00 C Fragrance 0.150 The water is heated to 80 degrees C (176 degrees F) and the phase A materials are added with mixing. The phase B materials are preblended in a separate container, heated to 80 degrees C with mixing. The phase A and phase B materials are mixed together and cooled to 40 degrees C at which point the phase C materials are added with mixing. The stable activated oxygen may be added as part of the deionized water or added separately.

In either case it is present in an amount of between 0.1% and 35% of the final composition.

Clear Alcohol Free Mouth Wash Phase Material Amount in percentage A Deionized water 97.62 A Polyaxamer 407 0.200 A Sodium benzoate 0.10 B Menthol 0.08 B LRI 0.05 C Polysorbate 20 0.30 C LRI 0.06 C Flavor peppermint AM Todd 0.02 C Flavor spearmint 0.18 D Acesulfame K 0.10 D Xlatol 0.30 E Processed colostrum 1.00 The procedure for forming a concentrate includes (1) weighing the water and adding the Polaxmer 407 while stirring. (2) After the Polyaxamer has been dissolved, the sweeteners (phase D) are added. (3) Once the above are dissolved, take a small portion of the solution and add the spearmint and peppermint 1171/TD 129.1 flavors and heat with water to dissolve easily. These flavors can be dissolved without heating but it would need to added to the solution very slowly and with high speed stirring. (4) Weigh the menthol and LRI separately and heat them together to 32 to 35 degrees C with slow mixing and then cool to room temperature. (5) Weigh the peppermint and the second LRI quantity while heating to between 32-35 degrees C with slow mixing and then cool to room temperature. (6) Add the ingredients of (4) and (5) together and mix slowly. Add (6) to the water. To make a concentrate hold out 89.03% of the water. 10.97 then represents the concentrate. For example, to make 100 grams of finished goods,

100x89.03 =gm of water, the difference would be the amount of concentrate one needs to add. In this case it would be 10.97 grams. The stable activated oxygen may be added as part of the deionized water or added separately. In either case it is present in an amount of between 0.1% and 35% ofthe final composition.

Antiperspirant Spray Deodorant Phase Material Amount in percentage A Deionized water 61.67 A Crodafos N3 0.1 B Allantoin 0.1 B Benzylkonium chloride 0.10 B Glutamic acid 0.06 B Glycerine 0.5 C Denatured alcohol SD 40 10 C Chlorhydrol 50 w/w 25 D Rosemary extract 0.500 D Processed colostrum 1.00 D Fragrance 0.967 Mix phase A materials with rapid agitation until dispersed. Add the remaining ingredients, as listed in the order of phase B, C and D. The stable activated oxygen may be added as part of the deionized water or added separately. In either case it is present in an amount of between 0.1% and 35% of the final composition.

Roll on deodorant Phase Material Amount in percentage A Deionized water 86.14 A Methylparaben 0.144 A Disodium edetate BP88 0.100 A Allantoin 0.333 A Glycerine 0.750 A Diazolindyl urea 0.110 A Magnesium aluminum salislate 1.00 B Xantham gum 2.800 B Propyleneglycol 1.000 C Menthol 0.005 C Arlatone 3.000 C HesteterF.A.O. 1.500 C Cyclomethicone 0.600 C Propylparaben 0.050 D Rosemary extract 1.000 D Processed colostrum 1.00 D Fragrance 0.967 The water is heated to 78 degrees C and phase A materials are added with mixing. The phase B materials are premixed in a separate container. The phase C materials are added to the phase A materials with mixing and the resultant material is cooled to 45 degrees C.

The phase D materials are then added to the phase AC mixture and thereafter the phase B materials are added with mixing. The stable activated oxygen may be added as part of the

deionized water or added separately. In either case it is present in an amount of between 0.1% and 35% of the final composition.

Deodorant with vitamin stick Phase Material Amount in percentage A Glyceryl stearate and PEG 100 stearate 0.500 A Cyclomethicone 57.00 A Propylparaben 0.175 A Stearyl alcohol 34.453 A Evening primrose oil 1.00 B Rosemary extract 1.200 B Menthol 0.005 B Ascorbic acid 1.200 B Ascorbyl palmitate 0.500 C Processed colostrum 1.00 C Panthenol 1.00 C SD 40 denatured 1.00 alcohol C Fragrance 0.967 The phase A materials are heated to 78 degrees C with mixing. The phase B materials are then added with mixing. Premix the phase C materials in a separate container until clear and add the phase C materials to the phase AB materials while the mixtures are at 60 degrees C. The roll on containers are filled while the temperature is at about 55 degrees C. The activated oxygen may be added from a source material of a concentration of 330,000 parts per million as part of the denatured alcohol and in an amount of between 0.1% to 35% of the final composition.

Body. Face and Gel Wash Phase Material Amount in percentage A Deionized water 61.85 B Methylparaben 0.15 B Allantoin 0.10 B Sodium laureth sulfate 60% 15.00 B Polysorbate 80 3.20 B Propylparaben 0.10 B Peg 150 distearate 0.60 B Cocamidopropyl dimethyl 7.00 betane B Cocamide DEA 5.00 C Processed colostrum 1.00 D Aloe extract 2.00 D Vitamin E 0.50 D DMDM hydantoin .15 D Rosemary extract 0.50 D Chamomile extract 0.50 D Goldenseal extract 0.50 D Ginseng extract 0.50 D Silicone T3801 1.00 D Fragrance 0.35 D FD&C blue #1 0.0008 Heat water to 78 degrees C and add phase B materials while mixing. The addition is made one by one until dissolved. Cool with mixing to 40 degrees C and add phases C and

D to phase AB. The stable activated oxygen may be added as part of the deionized water or added separately. In either case it is present in an amount of between 0.1% and 35% of the final composition.

Bodv Lotion Phase Material Amount in percentage A Deionized water 71.648 A Allantoin 0.500 A Methylparaben 0.175 A Octyl palmitate 2.500 A Tea 0.320 A DL panthenol 0.400 A Sorbitol 70% 0.067 B Standamul 1000 9.600 B Isopropyl myristate 10.000 B Lecithin 0.500 B Propylparaben 0.140 B Steareth 2 (BRJ 72) 1.060 B Aloe oil 0.500 B Diazolidinyl Urea 0.200 B Cetamacrogol 1000 0.400 B Cetostearyl alcohol 0.500 C Vitamin A palmitate 0.050 C Vitamin E 0.400 C Processed colostrum 1.000 C Fragrance 0.040 The water is heated to 80 degrees C. Phase A is added to the water, one by one until dissolved, with mixing. The mixture is heated to 80 degrees C and phase B is added, one by one, with mixing until dissolved. Cool with mixing to 40 degrees C and add phase C to phases A and B. The stable activated oxygen may be added as part of the deionized water or added separately. In either case it is present in an amount of between 0.1% and 35% ofthe final composition.

Liquid Soap Phase Material Amount in percentage A Deionized water 58.36 A Sodium C14-16 olefin sulfonate 8.0 A Ammonium lauryl sulfate 19.3 A Cocamide DEA 6.5 A Glycerine 0.5 A Cocamidopropyl betaine 4.2 A Methylparaben 0.15 A Propylparaben 0.12 B Citric acid 0.1 B Sodium chloride 0.3 B Menthol 0.005 C Aloe extract 0.1 C Processed colostrum 1.0 C Fragrance 0.967

The water is heated to 75 degrees C and phase A materials are added with stirring. The mixture is then heated to 65 degrees C and the phase B materials are added. The mixture is then cooled to 40 degrees C and the phase C materials are added to the phase AB materials. The stable activated oxygen may be added as part of the deionized water or added separately. In either case it is present in an amount of between 0.1% and 35% of the final composition.

Hair Shampoo Phase Material Amount in percentage A Deionized water 53.15 B Cocamidropropyl hydrosultain 5.00 B Sodium lauryl sulfate 25% 12.00 B Camamile DEA 2.000 B Sodium lauryl ester 18.00 sulfate 30% B Polysorbate 80 1.300 C PPG-5 ceteth- 10 phosphate 2.000 C Cocodimonium hydroxypropyl Oxyethyl cellulose 3.000 C Eucalyptus oil 0.01 C Menthol 0.005 C Sodium chloride 1.40 C Methylparaben 0.15 C DMDM hydantoin 0.15 D Processed colostrum 1.00 D Vitamin E 0.04 The water is heated to 78 degrees C and the phase B ingredients are added while mixing.

The mixture is then cooled to 60 degrees C and the phase C ingredients are added with

stirring. The phase ABC material is cooled to 40 degrees C and the phase D material is added while mixing. The stable activated oxygen may be added as part of the deionized water or added separately. In either case it is present in an amount of between 0.1% and 35% ofthe final composition.

Liquid Make-up Phase Material Amount in percentage A Deionized water 10.00 A Magnesium aluminum 0.30 silicate A Cellulose gum 0.11 B Deionized water 0.15 B Glycerine 3.00 B Lecithin 1.20 B Triethanolamine 99% 1.20 C Talc 4.77 C Iron oxide yellow 0.80 C Iron oxide red 0.60 C Iron oxide brown 0.22 C Titanium dioxide 4.77 D Propylparaben 0.22 D Stearic acid 2.60 D Stearamide MEA-stearate 3.00 D Mineral oil and lanolin alcohol 6.00 D Octyl Palmitate 6.50 E Processed colostrum 1.00 E Fragrance (as needed for 100%)

Preblend phase A materials and add slowly with agitation. Preblend phase B materials.

Add phase C materials to phase B mixture and mix until the pigments are completely wetted out. Add phase A materials to phase BC with mixing and pass through suitable milling equipment to insure that pigments are dispersed, then heat to 78 degrees C. The phase D materials are weighed out and heated in a separate container to 78 degrees C and then added to phase ABC materials with mixing. The resultant mixture is cooled to 40 degrees C and phase E is added with mixing. The stable activated oxygen may be added as part of the deionized water or added separately. In either case it is present in an amount of between 0.1% and 35% of the final composition.

Hair Conditioner Phase Material Amount in percentage A Deionized water 95.55 B Stearylaminopropyl dimethylamine 1.00 B Phosphoric acid 0.9000 B Eucalyptus oil 0.01 B Menthol 0.005 B Sodium chloride 0.30 B Methyl paraben 0.15 B DMDM hydantoin 0.15 C Processed colostrum 1.00 C Vitamin E .004 The deionized water is heated to 78 degrees C and the first component of the phase B materials is added while mixing and maintaining the temperature at 78 degrees C. The remaining materials of phase B are then added with mixing. The mixture is then cooled to

40 degrees C and the phase C materials are added with mixing. Again, the stable activated oxygen may be added as part of the deionized water or added separately. In either case it is present in an amount of between 0.1% and 35% ofthe final composition.

Curl activator Phase Material Amount in percentage A Deionized water 81.84 A Stearyl dimethyl benzyl ammonium chloride 0.66 A Glycerine 10.00 A SHEBU 0.45 A DL panthenol 0.5 A PEG 40 jojoba oil 0.45 A Pationic SSL 3.00 A Grillotin LSE 87K 1.00 B Propylene glycol and diazolidnyl urea and methyl and propyl paraben 1.00 B Processed colostrum 1.0 B Fragrance 0.10 The water is heated to 65 degrees C and the phase A materials are added while mixing.

The mixture is then cooled to 40 degrees C and the phase B materials are added while mixing. Again, the stable activated oxygen may be added as part of the deionized water or added separately. In either case it is present in an amount of between 0.1% and 35% of the final composition.

Tooth Whitening Stick Material Amount by percentage Polysorbate 20 1.0 Peppermint (Mentha piperita) Oil 0.875 Hydrogen peroxide 0.2 Sodium saccharin 0.30 Polyoximer 407 0.187 sodium benzoate <0.5 potassium sorbate <0.5 Processed Colostrum 0.06 5% stabilized oxygen balance to 100% (water and stabilized oxygen) Mouthwash and Gargle Material Amount by percentage Polysorbate 20 1.0 Peppermint (Mentha piperita) Oil 0.875 Hydrogen peroxide 0.2 Sodium saccharin 0.30 Polyoximer 407 0.187 sodium benzoate <0.5 potassium sorbate <0.5 Colostrum 0.06 5% stabilized oxygen balance to 100% (water and stabilized oxygen) It is apparent that a variety of products may be formulated in accordance with this invention, in addition to those given above. In many cases a conventional well known

carrier may be used for the particular product and processed stable activated oxygen and/or colostrum may be added to the base formulation. As mentioned, the processed colostrum may be used in amounts greater or less than the 1% by weight given in the above examples, i.e., as much as 5% by weight or less than 1%, with the 1% amount being preferred for cost and benefit reasons. In the case of the activated oxygen, amounts greater than 0.1% (over and above the normal amount of dissolved oxygen) and as much as 35% may be used, as already noted.

Typical other materials prepared in accordance with this invention include breath sprays with wintergreen, eye gels, insect bite relief sprays or ointments or salves, sports spays and arthritis relief sprays or ointments, first aid gels (for example, with lidocaine hydrochloride), astringent materials, alcohol free douche materials, lip balms, sunscreen lotions, hair root stimulators, nail conditioner and revitalizer, after sun skin repair products, to mention only a few.

It is contemplated that numerous changes, modifications and/or additions may be made to the specific embodiments of the present invention described in the detailed description without departing from the spirit and scope of the present invention.

Accordingly, it is intended that the scope of this patent be limited only by the scope of the appended claims and equivalents thereof.