Title:
IMPROVED INHIBITOR NUCLEIC ACIDS
Document Type and Number:
WIPO Patent Application WO2006001810
Kind Code:
A3
Abstract:
The present invention provides methods and compositions for attenuating expression of a target gene in vivo. In general, the method includes administering RNAi constructs (such as small-interfering RNAs (i.e., siRNAs) that are targeted to particular mRNA sequences, or nucleic acid material that can produce siRNAs in a cell), in an amount sufficient to attenuate expression of a target gene by an RNA interference mechanism. In particular, the RANi constructs include one or more modifications to improve serum stability and cellular uptake and to avoid non-specific effect.
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Inventors:
DAVIS MARK E (US)
Application Number:
PCT/US2004/022683
Publication Date:
February 16, 2006
Filing Date:
July 15, 2004
Export Citation:
Assignee:
CALIFORNIA INST OF TECHN (US)
DAVIS MARK E (US)
DAVIS MARK E (US)
International Classes:
A61K48/00; A61L27/54; A61L31/16; C07H21/02; C12N15/11; C12N15/113; C12Q1/68; A61K38/00; (IPC1-7): C12N15/11; A61K48/00; C07H21/00
Domestic Patent References:
| WO2004078941A2 | 2004-09-16 |
Foreign References:
| US20030104401A1 | 2003-06-05 |
Other References:
PARK WEE-SUNG ET AL: "Inhibition of HIV-1 replication by a new type of circular dumbbell RNA/DNA chimeric oligonucleotides", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 270, no. 3, 21 April 2000 (2000-04-21), pages 953 - 960, XP002151277, ISSN: 0006-291X
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