IMPROVED METHOD FOR CRYSTALLIZATION OF AZETIDINONECARBOXYLIC ACID

Title:

IMPROVED METHOD FOR CRYSTALLIZATION OF AZETIDINONECARBOXYLIC ACID

Document Type and Number:

WIPO Patent Application WO/2007/145260

Kind Code:

A1

Abstract:

Disclosed is a method for the crystallization of (2R)-2-[(3S,4S)-3-[(1R)-1-(tert-butyldimethylsilyl- oxy)ethyl]-2-oxoazetidin-4-yl]propionic acid. The method is characterized in that the crystallization of the compound is achieved by mixing a solution having the compound dissolved therein with a substituted aromatic hydrocarbon solvent and/or a halogenated hydrocarbon solvent. The method enables to produce a crystal of the compound at high purity and in a high yield, while keeping the content of a 2S isomer at a low level.

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Inventors:

NISHINO KEITA (JP)
KOGA TERUYOSHI (JP)
FUKAE MASAFUMI (JP)
UEDA YASUYOSHI (JP)

Application Number:

PCT/JP2007/061937

Publication Date:

December 21, 2007

Filing Date:

June 13, 2007

Export Citation:

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Assignee:

KANEKA CORP (JP)
NISHINO KEITA (JP)
KOGA TERUYOSHI (JP)
FUKAE MASAFUMI (JP)
UEDA YASUYOSHI (JP)

International Classes:

C07F7/18

Domestic Patent References:

WO2006028037A1	2006-03-16
WO2004103966A1	2004-12-02
WO2002012230A1	2002-02-14

Foreign References:

JPH05170733A	1993-07-09
JPH0725848A	1995-01-27
JP2000044538A	2000-02-15
JPH05105660A	1993-04-27
JPH04368365A	1992-12-21

Other References: