Title:
IMPROVED METHOD FOR OBTAINING BETULINIC ACID
Document Type and Number:
WIPO Patent Application WO2003066659
Kind Code:
A3
Abstract:
The invention relates to an improved method for obtaining highly pure, crystalline betulinic acid from a methanolic extract of ground plane bark and/or plane rind. The invention also relates to a highly pure, crystalline betulinic acid, which is solvated with an equivalent of ethanol.
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Inventors:
SAUTER MARKUS (DE)
Application Number:
PCT/EP2003/000905
Publication Date:
December 24, 2003
Filing Date:
January 30, 2003
Export Citation:
Assignee:
BOEHRINGER INGELHEIM PHARMA (DE)
SAUTER MARKUS (DE)
SAUTER MARKUS (DE)
International Classes:
A61K36/18; A61P35/00; A61K31/56; C07J53/00; C07J63/00; (IPC1-7): C07J63/00; A61K31/56
Domestic Patent References:
| WO2001010885A2 | 2001-02-15 |
Foreign References:
| DE19713768A1 | 1998-10-08 | |||
| US6264998B1 | 2001-07-24 |
Other References:
ROBERTSON A ET AL: "POLYTERPENOID COMPOUNDS PART I. BETULIC ACID FROM CORNUS FLORIDA, L", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY, LONDON, GB, 1939, pages 1267 - 1273, XP001025917, ISSN: 0368-1769
BRUCKNER V ET AL: "OCCURRENCE OF BETULINIC ACID IN THE BARK OF THE PLANE TREE", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY, LONDON, GB, 1948, pages 948 - 951, XP001080318, ISSN: 0368-1769
BRUCKNER V ET AL: "OCCURRENCE OF BETULINIC ACID IN THE BARK OF THE PLANE TREE", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL SOCIETY, LONDON, GB, 1948, pages 948 - 951, XP001080318, ISSN: 0368-1769
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