Title:
AN IMPROVED PROCESS FOR THE PREPARATION OF DOLUTEGRAVIR
Document Type and Number:
WIPO Patent Application WO/2014/128545
Kind Code:
A3
Abstract:
The present invention provides (R)-3-Amino-1-butanol (D)-tartarate (IIb); process for its preparation and its conversion to Dolutegravir. The present invention also provides an improved process for the preparation of Dolutegravir (I) or pharmaceutically acceptable salts wherein compound (XVI) is reacted with an optically active acid addition salt of (R)-3-amino-1-butanol (lla).
Inventors:
BUDIDET SHANKAR REDDY (IN)
DUSSA NAGESWAR (IN)
KAKI GOWRISANKAR RAO (IN)
YATCHERLA SRINIVASA RAO (IN)
SANAPUREDDY JAGAN MOHAN REDDY (IN)
DANDA SUBBA REDDY (IN)
KATUROJU SRINIVASACHARY (IN)
MEENAKSHISUNDERAM SIVAKUMARAN (IN)
DUSSA NAGESWAR (IN)
KAKI GOWRISANKAR RAO (IN)
YATCHERLA SRINIVASA RAO (IN)
SANAPUREDDY JAGAN MOHAN REDDY (IN)
DANDA SUBBA REDDY (IN)
KATUROJU SRINIVASACHARY (IN)
MEENAKSHISUNDERAM SIVAKUMARAN (IN)
Application Number:
PCT/IB2014/000149
Publication Date:
November 06, 2014
Filing Date:
February 07, 2014
Export Citation:
Assignee:
AUROBINDO PHARMA LTD (IN)
BUDIDET SHANKAR REDDY (IN)
DUSSA NAGESWAR (IN)
KAKI GOWRISANKAR RAO (IN)
YATCHERLA SRINIVASA RAO (IN)
SANAPUREDDY JAGAN MOHAN REDDY (IN)
DANDA SUBBA REDDY (IN)
KATUROJU SRINIVASACHARY (IN)
MEENAKSHISUNDERAM SIVAKUMARAN (IN)
BUDIDET SHANKAR REDDY (IN)
DUSSA NAGESWAR (IN)
KAKI GOWRISANKAR RAO (IN)
YATCHERLA SRINIVASA RAO (IN)
SANAPUREDDY JAGAN MOHAN REDDY (IN)
DANDA SUBBA REDDY (IN)
KATUROJU SRINIVASACHARY (IN)
MEENAKSHISUNDERAM SIVAKUMARAN (IN)
International Classes:
C07C213/02; C07C213/10; C07D498/14
Domestic Patent References:
| WO2011119566A1 | 2011-09-29 |
Foreign References:
| US20110275855A1 | 2011-11-10 |
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