Title:
AN IMPROVED PROCESS FOR THE PREPARATION OF DUTASTERIDE
Document Type and Number:
WIPO Patent Application WO/2011/004242
Kind Code:
A3
Abstract:
The present invention provides an improved process for the preparation of Dutasteride (I) which comprises: (i) reacting 4-aza-5α-androst-l -en-3-one-17β-carboxylic acid (VII), Formula VII with sulfonic acid anhydride (RSO2)2O in presence of base to produce an intermediate compound of Formula (XIII), wherein R represents C1-6 alkyl, C1-6 halo alkyl, C6-10 aryl, halo aryl; (ii) condensing compound of Formula (XIII) with 2,5-bis(trifluoromethyl)aniline (III), Formule (III) in the presence or absence of a base to produce Dutasteride (I).
Inventors:
MALLELA SAMBHU PRASAD SARMA (IN)
NANDI SUKUMAR (IN)
GONA BALANARASIMHA REDDY (IN)
AKKINA NARESH (IN)
ANANTA RANI (IN)
AMINUL ISLAM (IN)
MEENAKSHISUNDERAM SIVAKUMARAN (IN)
NANDI SUKUMAR (IN)
GONA BALANARASIMHA REDDY (IN)
AKKINA NARESH (IN)
ANANTA RANI (IN)
AMINUL ISLAM (IN)
MEENAKSHISUNDERAM SIVAKUMARAN (IN)
Application Number:
PCT/IB2010/001661
Publication Date:
April 21, 2011
Filing Date:
July 07, 2010
Export Citation:
Assignee:
AUROBINDO PHARMA LTD (IN)
MALLELA SAMBHU PRASAD SARMA (IN)
NANDI SUKUMAR (IN)
GONA BALANARASIMHA REDDY (IN)
AKKINA NARESH (IN)
ANANTA RANI (IN)
AMINUL ISLAM (IN)
MEENAKSHISUNDERAM SIVAKUMARAN (IN)
MALLELA SAMBHU PRASAD SARMA (IN)
NANDI SUKUMAR (IN)
GONA BALANARASIMHA REDDY (IN)
AKKINA NARESH (IN)
ANANTA RANI (IN)
AMINUL ISLAM (IN)
MEENAKSHISUNDERAM SIVAKUMARAN (IN)
International Classes:
C07J73/00
Domestic Patent References:
WO1995007927A1 | 1995-03-23 | |||
WO2003027132A2 | 2003-04-03 | |||
WO2009083258A2 | 2009-07-09 |
Foreign References:
US20070173523A1 | 2007-07-26 | |||
US5536714A | 1996-07-16 |
Other References:
ZHANG KUI-PING ET AL: "Synthesis of dutasteride", JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES, BEIJING, vol. 16, no. 3, 1 January 2007 (2007-01-01), pages 233 - 235, XP008107185, ISSN: 1003-1057
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