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Title:
AN IMPROVED PROCESS FOR THE PREPARATION OF DUTASTERIDE
Document Type and Number:
WIPO Patent Application WO/2011/004242
Kind Code:
A3
Abstract:
The present invention provides an improved process for the preparation of Dutasteride (I) which comprises: (i) reacting 4-aza-5α-androst-l -en-3-one-17β-carboxylic acid (VII), Formula VII with sulfonic acid anhydride (RSO2)2O in presence of base to produce an intermediate compound of Formula (XIII), wherein R represents C1-6 alkyl, C1-6 halo alkyl, C6-10 aryl, halo aryl; (ii) condensing compound of Formula (XIII) with 2,5-bis(trifluoromethyl)aniline (III), Formule (III) in the presence or absence of a base to produce Dutasteride (I).

Inventors:
MALLELA SAMBHU PRASAD SARMA (IN)
NANDI SUKUMAR (IN)
GONA BALANARASIMHA REDDY (IN)
AKKINA NARESH (IN)
ANANTA RANI (IN)
AMINUL ISLAM (IN)
MEENAKSHISUNDERAM SIVAKUMARAN (IN)
Application Number:
PCT/IB2010/001661
Publication Date:
April 21, 2011
Filing Date:
July 07, 2010
Export Citation:
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Assignee:
AUROBINDO PHARMA LTD (IN)
MALLELA SAMBHU PRASAD SARMA (IN)
NANDI SUKUMAR (IN)
GONA BALANARASIMHA REDDY (IN)
AKKINA NARESH (IN)
ANANTA RANI (IN)
AMINUL ISLAM (IN)
MEENAKSHISUNDERAM SIVAKUMARAN (IN)
International Classes:
C07J73/00
Domestic Patent References:
WO1995007927A11995-03-23
WO2003027132A22003-04-03
WO2009083258A22009-07-09
Foreign References:
US20070173523A12007-07-26
US5536714A1996-07-16
Other References:
ZHANG KUI-PING ET AL: "Synthesis of dutasteride", JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES, BEIJING, vol. 16, no. 3, 1 January 2007 (2007-01-01), pages 233 - 235, XP008107185, ISSN: 1003-1057
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