IMPROVED PROCESS FOR THE PREPARATION OF STABLE NITROXYL RADICALS

Title:

IMPROVED PROCESS FOR THE PREPARATION OF STABLE NITROXYL RADICALS

Document Type and Number:

WIPO Patent Application WO2007093452

Kind Code:

A8

Abstract:

Process for the preparation of stable nitroxyl radicals (I) starting from N-benzylphthalimide in two steps. In the first step, the intermediate N-benzyl-1, 1, 3, 3-tetra- alkylisoindoline is prepared by treatment with a Grignard reagent, prepared in methyl-tert-butyl ether, of N- benzylphthalimide, obtained in the same reaction environ - ment starting from phthalic anhydride and benzylamine. In the second step, the N-benzyl-1, 1, 3 , 3-tetra- alkylisoindoline is transformed into the nitroxyl radical by hydrogenolysis and subsequent oxidation with hydrogen peroxide in the presence of a catalyst selected from acids and salts of polymolybdic or polytungstic acids.

Inventors:

CALDARARO MARIA (IT)
PO' RICCARDO (IT)
RICCI MARCO (IT)

Application Number:

PCT/EP2007/001879

Publication Date:

May 08, 2008

Filing Date:

February 09, 2007

Export Citation:

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Assignee:

POLIMERI EUROPA SPA (IT)
CALDARARO MARIA (IT)
PO' RICCARDO (IT)
RICCI MARCO (IT)

International Classes:

C07D209/44

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