Title:
IMPROVED PROCESS FOR PRODUCING INTERMEDIATE FOR SIDE CHAIN OF CARBAPENEM
Document Type and Number:
WIPO Patent Application WO/2010/073706
Kind Code:
A1
Abstract:
Disclosed is a process for producing a pyrrolidine derivative usable as an intermediate for the production of a side chain of a carbapenem compound in a simple manner and in high yield, which utilizes a readily applicable and relatively inexpensive reagent and is not required to isolate a thiocarboxylic acid (an intermediate).
Specifically, a reaction is carried out by adding an aqueous metal sulfide solution to a compound represented by formula (2) at an agitation power consumption per unit volume of 0.2 kW/m3 or more while adjusting the value calculated by dividing the amount of the aqueous metal sulfide solution added per second by the total amount of the aqueous metal sulfide solution added to 0.003 to 0.2.
Inventors:
AGENO, Takafumi (1-8 Takasagocho Miyamaecho, Takasago-sh, Hyogo 88, 〒6768688, JP)
揚野貴文 (〒88 兵庫県高砂市高砂町宮前町１－８株式会社カネカ内 Hyogo, 〒6768688, JP)
OKAJIMA, Motonori (1-8 Takasagocho Miyamaecho, Takasago-sh, Hyogo 88, 〒6768688, JP)
揚野貴文 (〒88 兵庫県高砂市高砂町宮前町１－８株式会社カネカ内 Hyogo, 〒6768688, JP)
OKAJIMA, Motonori (1-8 Takasagocho Miyamaecho, Takasago-sh, Hyogo 88, 〒6768688, JP)
Application Number:
JP2009/007261
Publication Date:
July 01, 2010
Filing Date:
December 25, 2009
Export Citation:
Assignee:
KANEKA CORPORATION (2-4 Nakanoshima 3-chome, Kita-ku Osaka-sh, Osaka 88, 〒5308288, JP)
株式会社カネカ (〒88 大阪府大阪市北区中之島三丁目２－４ Osaka, 〒5308288, JP)
AGENO, Takafumi (1-8 Takasagocho Miyamaecho, Takasago-sh, Hyogo 88, 〒6768688, JP)
揚野貴文 (〒88 兵庫県高砂市高砂町宮前町１－８株式会社カネカ内 Hyogo, 〒6768688, JP)
株式会社カネカ (〒88 大阪府大阪市北区中之島三丁目２－４ Osaka, 〒5308288, JP)
AGENO, Takafumi (1-8 Takasagocho Miyamaecho, Takasago-sh, Hyogo 88, 〒6768688, JP)
揚野貴文 (〒88 兵庫県高砂市高砂町宮前町１－８株式会社カネカ内 Hyogo, 〒6768688, JP)
International Classes:
C07D495/08; C07D207/16
Attorney, Agent or Firm:
KANEKA CORPORATION (2-4 Nakanoshima 3-chome, Kita-ku Osaka-sh, Osaka 88, 〒5308288, JP)
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