Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
IMPROVED PRODUCTION OF BACTERIAL STRAINS CROSS REFERENCE TO RELATED APPLICATIONS
Document Type and Number:
WIPO Patent Application WO2004033421
Kind Code:
A3
Abstract:
The present invention provides methods to enhance production of desired products and increase the growth rate of a bacterial strain by inactivating an endogenous arcA and optionally overexpressing a ppc gene.

Inventors:
CERVIN MARGUERITE A (US)
SOUCAILLE PHILIPPE (FR)
TRIMBUR DONALD E (US)
VALLE FERNANDO (US)
Application Number:
US0331445W
Publication Date:
November 11, 2004
Filing Date:
October 03, 2003
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
GENENCOR INTERNATIONAL, INC.
CERVIN, MARGUERITE, A.
SOUCAILLE, PHILIPPE
TRIMBUR, DONALD, E.
VALLE, FERNANDO
International Classes:
C12N1/20; C12N15/70; C12P7/06; C12P7/18; C12P7/20; C12P7/28; C12P7/40; C12P7/44; C12P7/46; C12P13/04; C07D; (IPC1-7): C12N1/20
Other References:
JEON ET AL: 'Multimerization of phosphorylated and non-phosphorylated ArcA is necessary for the response regulator function of the Arc two-component signal transduction system' J. OF BIOLOGICAL CHEMISTRY vol. 276, no. 44, 02 November 2001, pages 40873 - 40879, XP002978484
CUNNINGHAM ET AL: 'Transcription and transcript processing in the sdhCDAB-sucABCD operon of Escherichia coli' MICROBIOLOGY vol. 144, 1998, pages 2113 - 2123, XP002978485
VAN DER REST ET AL: 'Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Escherichia coli' JOURNAL OF BACTERIOLOGY vol. 182, no. 24, December 2000, pages 6892 - 6899, XP002179953
WYBORN ET AL: 'Expression of the Escherichia coli yfiD gene responds to intracellular pH and reduces the accumulation of acidic metabolic end products' MICROBIOLOGY vol. 148, 2002, pages 1015 - 1026, XP002284817
See also references of EP 1546304A2
Download PDF: