Title:
IMPROVED PRODUCTION OF CLAVULANIC ACID BY GENETIC ENGINEERING OF STREPTOMYCES CLAVULIGERUS
Document Type and Number:
WIPO Patent Application WO2007030772
Kind Code:
A9
Abstract:
Genetically engineered Streptomyces clavuligerus strains with improved capabilities to produce clavulanic acid are provided. The strains are genetically engineered by disrupting newly identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) genes. This results in an increased intracelluar pool of the clavulanic acid precursor D-glyceraldehyde-3-phosphate (D-G3P), and increased clavulanic acid production. Clavulanic acid production may be further increased by supplying arginine to the medium in which the S.
Inventors:
TOWNSEND CRAIG A (US)
LI RONG-FENG (US)
LI RONG-FENG (US)
Application Number:
PCT/US2006/035172
Publication Date:
May 15, 2008
Filing Date:
September 08, 2006
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
TOWNSEND CRAIG A (US)
LI RONG-FENG (US)
TOWNSEND CRAIG A (US)
LI RONG-FENG (US)
International Classes:
C12P37/00
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