Title:
IMPROVED PRODUCTION OF FATTY ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2013/152051
Kind Code:
A3
Abstract:
The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.
Inventors:
GREENFIELD DEREK L (US)
SCHIRMER ANDREAS W (US)
CLARKE ELIZABETH J (US)
GROBAN ELI S (US)
DA COSTA BERNARDO M (US)
HU ZHIHAO (US)
HOLDEN KEVIN
HELMAN NOAH
SCHIRMER ANDREAS W (US)
CLARKE ELIZABETH J (US)
GROBAN ELI S (US)
DA COSTA BERNARDO M (US)
HU ZHIHAO (US)
HOLDEN KEVIN
HELMAN NOAH
Application Number:
PCT/US2013/035037
Publication Date:
December 12, 2013
Filing Date:
April 02, 2013
Export Citation:
Assignee:
LS9 INC (US)
GREENFIELD DEREK L (US)
SCHIRMER ANDREAS W (US)
CLARKE ELIZABETH J (US)
GROBAN ELI S (US)
DA COSTA BERNARDO M (US)
HU ZHIHAO (US)
HOLDEN KEVIN
HELMAN NOAH
GREENFIELD DEREK L (US)
SCHIRMER ANDREAS W (US)
CLARKE ELIZABETH J (US)
GROBAN ELI S (US)
DA COSTA BERNARDO M (US)
HU ZHIHAO (US)
HOLDEN KEVIN
HELMAN NOAH
International Classes:
C12N9/04; C12N9/00; C12N9/02; C12N9/10; C12N9/12; C12N9/88; C12N9/90; C12P7/64
Domestic Patent References:
| WO2012009660A2 | 2012-01-19 | |||
| WO2007136762A2 | 2007-11-29 | |||
| WO2013019647A1 | 2013-02-07 |
Foreign References:
| US20100242345A1 | 2010-09-30 | |||
| US20110151526A1 | 2011-06-23 | |||
| US20100274033A1 | 2010-10-28 |
Other References:
R. J. HEATH: "The Enoyl-[acyl-carrier-protein] Reductases FabI and FabL from Bacillus subtilis", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 51, 27 September 2000 (2000-09-27), pages 40128 - 40133, XP055083356, ISSN: 0021-9258, DOI: 10.1074/jbc.M005611200
HELMUT BERGLER ET AL: "The enoyl-[acyl-carrier-protein] reductase (FabI) of Escherichia coli, which catalyzes a key regulatory step in fatty acid biosynthesis, accepts NADH and NADPH as cofactors and is inhibited by palmitoyl-CoA", EUR. J. BIOCHEM., vol. 242, 1 January 1996 (1996-01-01), pages 689 - 694, XP055083347
HELMUT BERGLER ET AL: "The enoyl-[acyl-carrier-protein] reductase (FabI) of Escherichia coli, which catalyzes a key regulatory step in fatty acid biosynthesis, accepts NADH and NADPH as cofactors and is inhibited by palmitoyl-CoA", EUR. J. BIOCHEM., vol. 242, 1 January 1996 (1996-01-01), pages 689 - 694, XP055083347
Attorney, Agent or Firm:
HAJOS, Brigitte (600 Gateway BoulevardSouth San Francisco, CA, US)
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