IMPROVED QUANTAMATRIX ASSAY PLATFORM-BASED, DIAGNOSTIC METHOD CAPABLE OF SIMULTANEOUSLY IDENTIFYING DETECTION OF MYCOBACTERIUM TUBERCULOSIS AND RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS TO RIFAMPIN, ISONIAZID, ETHAMBUTOL, QUINOLONE, SECOND LINE INJECTABLE DRUGS SUCH AS AMIKACIN, KANAMYCIN, AND CAPEOMYCIN, AND STREPTOMYCIN DRUGS, AND KIT THEREFOR - UNIV INDUSTRY FOUNDATION YONSEI UNIV WONJU CAMPUS

Title:

IMPROVED QUANTAMATRIX ASSAY PLATFORM-BASED, DIAGNOSTIC METHOD CAPABLE OF SIMULTANEOUSLY IDENTIFYING DETECTION OF MYCOBACTERIUM TUBERCULOSIS AND RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS TO RIFAMPIN, ISONIAZID, ETHAMBUTOL, QUINOLONE, SECOND LINE INJECTABLE DRUGS SUCH AS AMIKACIN, KANAMYCIN, AND CAPEOMYCIN, AND STREPTOMYCIN DRUGS, AND KIT THEREFOR

Document Type and Number:

WIPO Patent Application WO/2019/225959

Kind Code:

A1

Abstract:

The present invention relates to an improved QuantaMatrix assay platform-based, diagnostic method capable of simultaneously identifying the detection of Mycobacterium tuberculosis and nontuberculous mycobacteria and the resistance of Mycobacterium tuberculosis to rifampin, isoniazid, ethambutol, quinolone, second line injectable drugs (KM, AMK, CAP), and streptomycin drugs, and a kit therefor. The present invention can reduce a time taken to separate and culture bacteria from a specimen in a drug resistance test and can conduct an effective drug sensitive test of multiple drug-resistant and extensively drug-resistant Mycobacterium tuberculosis in multiple specimens, whereby accurate and fast selection can be made of an anti-tuberculous agent in the treatment of tuberculosis patients, so that the present invention can be advantageously used for early treatment and infection spread prevention. In addition, the present invention can prevent the misdiagnosis and prescription errors that may be caused by the contamination or combined infection of nontuberculous mycobacteria.

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Inventors:

LEE HYE YOUNG (KR)
KIM YEUN (KR)
KIM SEO YONG (KR)
CHANG YUN HEE (KR)
LEE SU JI (KR)
HA SUN MOK (KR)

Application Number:

PCT/KR2019/006106

Publication Date:

November 28, 2019

Filing Date:

May 22, 2019

Export Citation:

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Assignee:

UNIV INDUSTRY FOUNDATION YONSEI UNIV WONJU CAMPUS (KR)

International Classes:

C12Q1/689; C12Q1/686

Foreign References:

JP2017530710A	2017-10-19
JP2004215542A	2004-08-05
KR20180038400A	2018-04-16

Other References:

WANG, HYE-YOUNG ET AL.: "Evaluation of the Quantamatrix Multiplexed Assay Platform system for simultaneous detection of Mycobacterium tuberculosis and the rifampicin resistance geue using cultured mycobacteria", INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol. 61, 2017, pages 107 - 113, XP085139527
WANG, HYE-YOUNG ET AL.: "Performance of the Quantamatrix Multiplexed Assay Platform system for the differentiation and identification of Mycobacterium species", JOURNAL OF MEDICAL MICROBIOLOGY, vol. 66, 2017, pages 777 - 787, XP055657066

Attorney, Agent or Firm:

KOO, Hyun Seo (KR)

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