Title:
IMPROVED αβ T PROCESSED CELL PRODUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2019/156145
Kind Code:
A1
Abstract:
Provided are a production method for cytotoxic T cells with increased recognition of cancer cells, a cancer treatment drug including said cytotoxic T cells, and a treatment method using said treatment drug.
Inventors:
TOYOFUKU TOSHIHIKO (JP)
SASAWATARI SHIGEMI (JP)
SASAWATARI SHIGEMI (JP)
Application Number:
PCT/JP2019/004357
Publication Date:
August 15, 2019
Filing Date:
February 07, 2019
Export Citation:
Assignee:
UNIV OSAKA (JP)
MEDINET CO LTD (JP)
MEDINET CO LTD (JP)
International Classes:
C12N5/078; A61K35/17; A61P31/04; A61P31/12; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P35/00; A61P35/02; C12N1/00; C12N5/0783
Domestic Patent References:
| WO2017142014A1 | 2017-08-24 |
Other References:
DREAU, DIDIER ET AL.: "Effects of 2-deoxy-D-glucose administration on immune parameters in mice", IMMUNOPHARMACOLOGY, vol. 39, 1998, pages 201 - 213, XP085644766, doi:10.1016/S0162-3109(98)00016-2
PALLADINO, MICHAEL A. ET AL.: "Characterization of IL-2-dependent cytotoxic T-cell clones - II. Cell-surface phenotypes, histochemical and ultrastructural properties", CELLULAR IMMUNOLOGY, vol. 76, no. 2, March 1983 (1983-03-01), pages 286 - 294, XP024001294
ROBSON, H. ET AL.: "Inhibition of T Cell -Mediated Cytolysis by 2-Deoxy-D-Glucose (2-DG) : Differential Effect of 2-DG on Effector Cells Isolated Early or Late After Alloantigenic Stimulation in Vitro", JOURNAL OF IMMUNOLOGY, vol. 122, no. 3, March 1979 (1979-03-01), pages 1067 - 1072, XP055629761
See also references of EP 3750988A4
PALLADINO, MICHAEL A. ET AL.: "Characterization of IL-2-dependent cytotoxic T-cell clones - II. Cell-surface phenotypes, histochemical and ultrastructural properties", CELLULAR IMMUNOLOGY, vol. 76, no. 2, March 1983 (1983-03-01), pages 286 - 294, XP024001294
ROBSON, H. ET AL.: "Inhibition of T Cell -Mediated Cytolysis by 2-Deoxy-D-Glucose (2-DG) : Differential Effect of 2-DG on Effector Cells Isolated Early or Late After Alloantigenic Stimulation in Vitro", JOURNAL OF IMMUNOLOGY, vol. 122, no. 3, March 1979 (1979-03-01), pages 1067 - 1072, XP055629761
See also references of EP 3750988A4
Attorney, Agent or Firm:
ASAMURA PATENT OFFICE, P.C. (JP)
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