Title:
IMPROVEMENT OF MEMORY OR LEARNING USING PEPTIDE AND OTHER COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2014/160138
Kind Code:
A3
Abstract:
The present invention generally relates to compositions and methods for topical or transdermal delivery, including treatment and prevention of learning and memory disorders, and enhancement of learning or memory. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (TRH) and/or GnRH (gonadotropin-releasing hormone). The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other structures containing nitric oxide and/or peptide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid "stick," etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
Inventors:
PERRICONE NICHOLAS V (US)
Application Number:
PCT/US2014/025898
Publication Date:
November 27, 2014
Filing Date:
March 13, 2014
Export Citation:
Assignee:
TRANSDERMAL BIOTECHNOLOGY INC (US)
International Classes:
A61K9/00; A61K38/22; A61K33/00; A61K47/14; A61P25/16; A61P25/28
Domestic Patent References:
| WO2009033777A1 | 2009-03-19 | |||
| WO2012030716A1 | 2012-03-08 | |||
| WO2012125214A1 | 2012-09-20 | |||
| WO2004060315A2 | 2004-07-22 | |||
| WO2003101480A1 | 2003-12-11 |
Foreign References:
| US20060058241A1 | 2006-03-16 | |||
| US6242421B1 | 2001-06-05 | |||
| US5434136A | 1995-07-18 | |||
| US20060142186A1 | 2006-06-29 | |||
| US20050074506A1 | 2005-04-07 | |||
| US20100292330A1 | 2010-11-18 |
Other References:
D'AMICO A V ET AL: "Luteinizing-hormone releasing hormone therapy and the risk of death from alzheimer disease", ALZHEIMER DISEASE AND ASSOCIATED DISORDERS, RAVEN PRESS, NEW YORK, NY, US, vol. 24, no. 1, January 2010 (2010-01-01), pages 85 - 89, XP009178127, ISSN: 0893-0341
GEIER DAVID A ET AL: "A clinical trial of combined anti-androgen and anti-heavy metal therapy in autistic disorders", NEUROENDOCRINOLOGY LETTERS, MAGHIRA & MAAS PUBLICATIONS, SE, vol. 27, no. 6, December 2006 (2006-12-01), pages 833 - 838, XP009178199, ISSN: 0172-780X
GEIER DAVID A ET AL: "A clinical trial of combined anti-androgen and anti-heavy metal therapy in autistic disorders", NEUROENDOCRINOLOGY LETTERS, MAGHIRA & MAAS PUBLICATIONS, SE, vol. 27, no. 6, December 2006 (2006-12-01), pages 833 - 838, XP009178199, ISSN: 0172-780X
Attorney, Agent or Firm:
CHEN, Tani (Greenfield & Sacks P.C.,600 Atlantic Avenu, Boston MA, US)
Download PDF: