Title:
IMPROVEMENTS IN OR RELATING TO MICROSPHERE-ENHANCED SPECTROSCOPY
Document Type and Number:
WIPO Patent Application WO/2019/002876
Kind Code:
A3
Abstract:
An apparatus (100) for carrying out microsphere-enhanced spectroscopy on a sample (15) is shown. Illumination of the sample (15) is provided by an illumination laser (11). A microsphere (1) is attached to the front lens of the objective lens assembly (2) by a column (13) of optically clear material. This allows the illumination radiation to be focused on the sample (15). Scattered radiation from the illuminated area is collected via the microsphere (1) and the objective lens assembly (2). The scattered radiation passes through the objective lens assembly (2), an optional adjustable pinhole (3) and dichroic mirror (4) to a notch filter (8). The filtered scattered radiation is incident upon an optical grating (6), and subsequently a detector. The provision of the microsphere (1) on a column (13) of optically clear material ensures that it can be retained in a desired alignment and at a desired separation from the front lens of the objective lens assembly (2).
Inventors:
STANESCU SORIN (GB)
VILAIN SEBASTIEN (GB)
GOH CHING TZU (GB)
LI LIN (GB)
VILAIN SEBASTIEN (GB)
GOH CHING TZU (GB)
LI LIN (GB)
Application Number:
PCT/GB2018/051819
Publication Date:
March 07, 2019
Filing Date:
June 28, 2018
Export Citation:
Assignee:
LIG NANOWISE LTD (GB)
International Classes:
G01J3/44; G01Q60/22; G02B3/00; G02B7/00; G02B7/02; G02B7/14; G02B21/00; G02B21/02; G02B21/16; G02B27/02; G02B27/56; G02B27/58
Other References:
DANTHAM V ET AL: "Enhancement of Raman scattering by two orders of magnitude using photonic nanojet of a microsphere", JOURNAL OF APPLIED PHYSICS, AMERICAN INSTITUTE OF PHYSICS, US, vol. 109, no. 10, 16 May 2011 (2011-05-16), pages 103103 - 103103, XP012146827, ISSN: 0021-8979, DOI: 10.1063/1.3590156
GERGELY HUSZKA ET AL: "Microsphere-based super-resolution scanning optical microscope", OPTICS EXPRESS, vol. 25, no. 13, 21 June 2017 (2017-06-21), US, pages 15079, XP055512807, ISSN: 1094-4087, DOI: 10.1364/OE.25.015079
NORLAND: "Norland Optical Adhesive 63", 23 June 2016 (2016-06-23), XP055513160, Retrieved from the Internet [retrieved on 20181008]
SORIN STANESCU ET AL: "Optical Scanning Nanoscope with Microsphere Attached Objective Lens for Super Resolution 3D Virtual Imaging", OPTICS IN THE LIFE SCIENCES CONGRESS, 5 April 2017 (2017-04-05), Washington, D.C., pages BoTu3A.5, XP055551617, ISBN: 978-1-943580-25-5, DOI: 10.1364/BODA.2017.BoTu3A.5
GERGELY HUSZKA ET AL: "Microsphere-based super-resolution scanning optical microscope", OPTICS EXPRESS, vol. 25, no. 13, 21 June 2017 (2017-06-21), US, pages 15079, XP055512807, ISSN: 1094-4087, DOI: 10.1364/OE.25.015079
NORLAND: "Norland Optical Adhesive 63", 23 June 2016 (2016-06-23), XP055513160, Retrieved from the Internet
SORIN STANESCU ET AL: "Optical Scanning Nanoscope with Microsphere Attached Objective Lens for Super Resolution 3D Virtual Imaging", OPTICS IN THE LIFE SCIENCES CONGRESS, 5 April 2017 (2017-04-05), Washington, D.C., pages BoTu3A.5, XP055551617, ISBN: 978-1-943580-25-5, DOI: 10.1364/BODA.2017.BoTu3A.5
Attorney, Agent or Firm:
WILSON GUNN (GB)
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