Title:
IMPROVING ENZYME AUGMENTATION THERAPIES BY MODIFYING GLYCOSYLATION
Document Type and Number:
WIPO Patent Application WO/2019/165369
Kind Code:
A3
Abstract:
Disclosed herein are enzymes with tunable pH dependence for use in treating various diseases, disorders, and conditions. In some embodiments, the enzyme is a peroxidase having a glycosylation pattern that is altered from that of the native enzyme. The enzyme can be administered to a patient with a lysosomal storage disorder, such as macular degeneration, wherein the enzyme is less active in compartments and organelles having physiologic pH, and is relatively more active in compartments and organelles having a pH that is lower than physiologic pH.
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Inventors:
MOODY KELSEY (US)
WOLFE AARON (US)
BLANDEN ADAM (US)
GROHN KRIS (US)
KELLY KATHLEEN (US)
DEROSA JENNIFER (US)
WOLFE AARON (US)
BLANDEN ADAM (US)
GROHN KRIS (US)
KELLY KATHLEEN (US)
DEROSA JENNIFER (US)
Application Number:
PCT/US2019/019420
Publication Date:
October 17, 2019
Filing Date:
February 25, 2019
Export Citation:
Assignee:
ICHOR THERAPEUTICS INC (US)
International Classes:
C12P19/04; C12P21/00
Foreign References:
US8143049B2 | 2012-03-27 | |||
US5153310A | 1992-10-06 | |||
US20100286067A1 | 2010-11-11 |
Attorney, Agent or Firm:
LEVITT, Kenneth E. et al. (US)
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