Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
IMPROVING ENZYME AUGMENTATION THERAPIES BY MODIFYING GLYCOSYLATION
Document Type and Number:
WIPO Patent Application WO/2019/165369
Kind Code:
A3
Abstract:
Disclosed herein are enzymes with tunable pH dependence for use in treating various diseases, disorders, and conditions. In some embodiments, the enzyme is a peroxidase having a glycosylation pattern that is altered from that of the native enzyme. The enzyme can be administered to a patient with a lysosomal storage disorder, such as macular degeneration, wherein the enzyme is less active in compartments and organelles having physiologic pH, and is relatively more active in compartments and organelles having a pH that is lower than physiologic pH.

Inventors:
MOODY KELSEY (US)
WOLFE AARON (US)
BLANDEN ADAM (US)
GROHN KRIS (US)
KELLY KATHLEEN (US)
DEROSA JENNIFER (US)
Application Number:
PCT/US2019/019420
Publication Date:
October 17, 2019
Filing Date:
February 25, 2019
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
ICHOR THERAPEUTICS INC (US)
International Classes:
C12P19/04; C12P21/00
Foreign References:
US8143049B22012-03-27
US5153310A1992-10-06
US20100286067A12010-11-11
Attorney, Agent or Firm:
LEVITT, Kenneth E. et al. (US)
Download PDF: