Title:
IN SITU PHASE CHANGE GEL SUSTAINED-RELEASE SYSTEM FOR SMALL MOLECULE DRUG AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/233148
Kind Code:
A1
Abstract:
An in situ phase change gel sustained-release preparation for a small molecule drug and a preparation method thereof. The in situ phase change gel sustained-release preparation comprises a small molecule drug comprising an active pharmaceutical ingredient, a phospholipid, Span, and an ethanol solution. The in situ phase change gel sustained-release preparation has a high concentration of phospholipids combined with Span, and is thus able to reduce the immediate-release of the small molecule drug and extend the release time, and is suitable for various administration routes, such as subcutaneous injection and external administration.
Inventors:
GONG TAO (CN)
SONG XU (CN)
ZHANG ZHIRONG (CN)
ZHANG YAN (CN)
WEI GUANGFEI (CN)
HU MEI (CN)
CHEN TIJIA (CN)
SUN XUN (CN)
FU YAO (CN)
SONG XU (CN)
ZHANG ZHIRONG (CN)
ZHANG YAN (CN)
WEI GUANGFEI (CN)
HU MEI (CN)
CHEN TIJIA (CN)
SUN XUN (CN)
FU YAO (CN)
Application Number:
PCT/CN2017/105682
Publication Date:
December 27, 2018
Filing Date:
October 11, 2017
Export Citation:
Assignee:
UNIV SICHUAN (CN)
YAOPHARMA CO LTD (CN)
YAOPHARMA CO LTD (CN)
International Classes:
A61K9/06; A61K31/06; A61K45/00; A61K47/10; A61K47/24; A61K47/26
Foreign References:
| CN103142468A | 2013-06-12 | |||
| CN102526753A | 2012-07-04 | |||
| CN103705442A | 2014-04-09 | |||
| CN107049932A | 2017-08-18 | |||
| CN102697741A | 2012-10-03 | |||
| CN102526753A | 2012-07-04 |
Other References:
See also references of EP 3643298A4
MX WANG: "Pharmacokinetic and pharmacodynamic study of a phospholipid-based phase separation gel for once a month administration of octreotide", JOURNAL OF CONTROLLED RELEASE, vol. 230, 2016, pages 45 - 56
M HU ET AL.: "Long-Acting Phospholipid Gel of Exenatide for Long-TermTherapy of Type II Diabetes", PHARM RES, vol. 33, 2016, pages 1318 - 1326
COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 140, 2016, pages 538 - 547
LIN Z: "Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity", JOURNAL OF CONTROLLED RELEASE, vol. 28, 2014, pages 161 - 70
MX WANG: "Pharmacokinetic and pharmacodynamic study of a phospholipid-based phase separation gel for once a month administration of octreotide", JOURNAL OF CONTROLLED RELEASE, vol. 230, 2016, pages 45 - 56
M HU ET AL.: "Long-Acting Phospholipid Gel of Exenatide for Long-TermTherapy of Type II Diabetes", PHARM RES, vol. 33, 2016, pages 1318 - 1326
COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 140, 2016, pages 538 - 547
LIN Z: "Novel thermo-sensitive hydrogel system with paclitaxel nanocrystals: High drug-loading, sustained drug release and extended local retention guaranteeing better efficacy and lower toxicity", JOURNAL OF CONTROLLED RELEASE, vol. 28, 2014, pages 161 - 70
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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