Title:
IN VITRO EMBRYO BLASTOCYST PREDICTION METHODS
Document Type and Number:
WIPO Patent Application WO/2013/181549
Kind Code:
A3
Abstract:
Methods, compositions and kits for determining the likelihood of reaching the blastocyst stage for one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
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Inventors:
CHEN KIM ALICE A (US)
LOEWKE KEVIN E (US)
SURAJ VAISHALI (US)
LOEWKE KEVIN E (US)
SURAJ VAISHALI (US)
Application Number:
PCT/US2013/043639
Publication Date:
January 23, 2014
Filing Date:
May 31, 2013
Export Citation:
Assignee:
AUXOGYN INC (US)
CHEN KIM ALICE A (US)
CHEN KIM ALICE A (US)
International Classes:
C12Q1/02; A61B17/435
Domestic Patent References:
| WO2012042228A2 | 2012-04-05 | |||
| WO2012163363A1 | 2012-12-06 |
Foreign References:
| US7963906B2 | 2011-06-21 | |||
| US20100041090A1 | 2010-02-18 | |||
| US20120095287A1 | 2012-04-19 |
Other References:
MESEGUER ET AL.: "The use of morphokinetics as a predictor of embryo implantation", HUMAN REPRODUCTION, vol. 26, no. 10, 9 August 2011 (2011-08-09), pages 2658 - 2671, XP055033123
LEMMEN ET AL.: "Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes", REPRODUCTIVE BIOMEDICINE ONLINE, vol. 17, no. 3., 30 July 2008 (2008-07-30), pages 385 - 391, XP003028429
CHAVEZ ET AL.: "Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage", NATURE COMMUNICATION (NCOMMS2249), 4 December 2012 (2012-12-04), XP055169858, Retrieved from the Internet [retrieved on 20131007]
ANTCZAK ET AL.: "Temporal and spatial aspects of fragmentation in early human embryos: possible effects on developmental competence and association with the differential eliminatior of regulatory proteins from polarized domains", HUMAN REPRODUCTION, vol. 14, no. 2, 1999, pages 429 - 477, XP055177940
KIRKEGAARD ET AL.: "Time-lapse monitoring as a tool for clinical embryo assessment", HUMAN REPRODUCTION, vol. 27, no. 5, 14 March 2012 (2012-03-14), pages 1277 - 1285, XP055177945
HLINKA ET AL.: "Time-lapse cleavage rating predicts human embryo viability.", PHYSIOL RES., vol. 61, no. 5, 14 December 2012 (2012-12-14), pages 513 - 525, XP055079684
LEMMEN ET AL.: "Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes", REPRODUCTIVE BIOMEDICINE ONLINE, vol. 17, no. 3., 30 July 2008 (2008-07-30), pages 385 - 391, XP003028429
CHAVEZ ET AL.: "Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage", NATURE COMMUNICATION (NCOMMS2249), 4 December 2012 (2012-12-04), XP055169858, Retrieved from the Internet
ANTCZAK ET AL.: "Temporal and spatial aspects of fragmentation in early human embryos: possible effects on developmental competence and association with the differential eliminatior of regulatory proteins from polarized domains", HUMAN REPRODUCTION, vol. 14, no. 2, 1999, pages 429 - 477, XP055177940
KIRKEGAARD ET AL.: "Time-lapse monitoring as a tool for clinical embryo assessment", HUMAN REPRODUCTION, vol. 27, no. 5, 14 March 2012 (2012-03-14), pages 1277 - 1285, XP055177945
HLINKA ET AL.: "Time-lapse cleavage rating predicts human embryo viability.", PHYSIOL RES., vol. 61, no. 5, 14 December 2012 (2012-12-14), pages 513 - 525, XP055079684
Attorney, Agent or Firm:
FULLER, Alyson C. et al. (1299 Pennsylvania AvenueSuite 70, Washington District of Columbia, US)
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